Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Col1a1tm1(tetO-Deptor)Dmsa
Name:	collagen, type I, alpha 1; targeted mutation 1, David M Sabatini
MGI ID:	MGI:5437855
Synonyms:	iDeptor
Gene:	Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1tm1(tetO-Deptor)Dmsa page

Germline Transmission:	Earliest citation of germline transmission: J:187378
Parent Cell Line:	KH2 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Inducible, Inserted expressed sequence, RMCE-ready) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Col1a1tm1(tetO-Deptor)Dmsa expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Deptor (MGI:2146322)   Col1a1tm1(tetO-Deptor)Dmsa expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note Not Specified tetO   Mutation details: Recombinase mediated cassette exchange in KH2 ES cells replaced the existing cassette at this locus with one encoding a tetO minimal promoter and Deptor coding sequence. (J:187378)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	160 strains or lines available

Original:	J:187378 Laplante M, et al., DEPTOR Cell-Autonomously Promotes Adipogenesis, and Its Expression Is Associated with Obesity. Cell Metab. 2012 Aug 8;16(2):202-12
All:	2 reference(s)