Phenotypes associated with this allele

• Allele Symbol: Col1a1^{tm1(tetO-Deptor)Dmsa}
• Allele Name: targeted mutation 1, David M Sabatini
• Allele ID: MGI:5437855
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Col1a1^tm1(tetO-Deptor)Dmsa/Col1a1^+ Gt(ROSA)26Sor^tm1(rtTA*M2)Jae/?	involves: 129S4/SvJae * C57BL/6 * C57BL/6J	MGI:5437856

Genotype
MGI:5437856

cx1

• Allelic Composition: Col1a1^{tm1(tetO-Deptor)Dmsa}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:187378 )

• doxycycline treated mice gain more weight on a high fat diet; not caused by a difference in food intake or locomotion

increased circulating leptin level ( J:187378 )

• in doxycycline treated mice on a high fat diet

increased triglyceride level ( J:187378 )

• MEFs treated with doxycycline and differentiated in adipocytes show increased triglyceride accumulation

adipose tissue

increased white adipose tissue amount ( J:187378 )

• in doxycycline treated mice on a high fat diet

liver/biliary system

increased liver weight ( J:187378 )

• in doxycycline treated mice on a high fat diet

hepatic steatosis ( J:187378 )

• in doxycycline treated mice on a high fat diet

growth/size/body

increased susceptibility to diet-induced obesity ( J:187378 )

• doxycycline treated mice gain more weight on a high fat diet; not caused by a difference in food intake or locomotion

increased liver weight ( J:187378 )

• in doxycycline treated mice on a high fat diet