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Spns2tm1.2Nmoc
Targeted Allele Detail
Summary
Symbol: Spns2tm1.2Nmoc
Name: SPNS lysolipid transporter 2, sphingosine-1-phosphate; targeted mutation 1.2, Naoki Mochizuki
MGI ID: MGI:5426395
Gene: Spns2  Location: Chr11:72342464-72380730 bp, - strand  Genetic Position: Chr11, 44.31 cM
Alliance: Spns2tm1.2Nmoc page
Spns2tm1.2Nmoc/Spns2tm1.2Nmoc mice exhibit symblepharon

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184558
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination of Spns2tm1.1Nmoc removes exon 2. RT-PCR confirmed the absence of full-length transcript. The protein product is expected to be functionally deffective. (J:184558)
Generation of the Spns2tm1.1Nmoc and Spns2tm1.2Nmoc alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spns2 Mutation:  28 strains or lines available
References
Original:  J:184558 Fukuhara S, et al., The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J Clin Invest. 2012 Apr 2;122(4):1416-26
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory