Phenotypes associated with this allele

• Allele Symbol: Spns2^tm1.2Nmoc
• Allele Name: targeted mutation 1.2, Naoki Mochizuki
• Allele ID: MGI:5426395
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spns2^tm1.2Nmoc/Spns2^tm1.2Nmoc	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5426399

Genotype
MGI:5426399

hm1

• Allelic Composition: Spns2^tm1.2Nmoc/Spns2^tm1.2Nmoc
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Spns2^tm1.2Nmoc/Spns2^tm1.2Nmoc mice exhibit symblepharon

immune system

increased CD4-positive, alpha-beta T cell number ( J:184558 )

• in the thymus

increased CD8-positive, alpha-beta T cell number ( J:184558 )

• in the thymus

increased single-positive T cell number ( J:184558 )

• mice exhibit an increase in the proportion of fully matured single positive T cells and decrease in semi-mature single positive T cells compared with wild-type mice

decreased leukocyte cell number ( J:184558 )

decreased immature B cell number ( J:184558 )

• in the blood

decreased transitional stage T1 B cell number ( J:184558 )

• in the spleen

decreased mature B cell number ( J:184558 )

• in the blood and bone marrow

decreased B-1 B cell number ( J:184558 )

• in the spleen

decreased follicular B cell number ( J:184558 )

decreased CD4-positive, alpha-beta T cell number ( J:184558 )

• in the blood, peripheral lymph nodes and spleen

decreased CD8-positive, alpha-beta T cell number ( J:184558 )

• in the blood, peripheral lymph nodes and spleen

abnormal B cell physiology ( J:184558 )

• immature B cells exhibit impaired egression from the bone marrow compared to in wild-type mice

abnormal T cell physiology ( J:184558 )

• single positive T cells exhibit impaired egression from the thymus compared with wild-type cells

vision/eye

symblepharon ( J:184558 )

• variable symblepharon

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:184558 )

• in the thymus

increased CD8-positive, alpha-beta T cell number ( J:184558 )

• in the thymus

increased single-positive T cell number ( J:184558 )

• mice exhibit an increase in the proportion of fully matured single positive T cells and decrease in semi-mature single positive T cells compared with wild-type mice

decreased leukocyte cell number ( J:184558 )

decreased immature B cell number ( J:184558 )

• in the blood

decreased transitional stage T1 B cell number ( J:184558 )

• in the spleen

decreased mature B cell number ( J:184558 )

• in the blood and bone marrow

decreased B-1 B cell number ( J:184558 )

• in the spleen

decreased follicular B cell number ( J:184558 )

decreased CD4-positive, alpha-beta T cell number ( J:184558 )

• in the blood, peripheral lymph nodes and spleen

decreased CD8-positive, alpha-beta T cell number ( J:184558 )

• in the blood, peripheral lymph nodes and spleen

abnormal B cell physiology ( J:184558 )

• immature B cells exhibit impaired egression from the bone marrow compared to in wild-type mice

abnormal T cell physiology ( J:184558 )

• single positive T cells exhibit impaired egression from the thymus compared with wild-type cells