Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Col1a1tm9(tetO-Dnmt3b_i1)Jae
Name:	collagen, type I, alpha 1; targeted mutation 9, Rudolf Jaenisch
MGI ID:	MGI:5313405
Synonyms:	tetO-Dnmt3b1
Gene:	Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1tm9(tetO-Dnmt3b_i1)Jae page

Germline Transmission:	Earliest citation of germline transmission: J:127808
Parent Cell Line:	KH2 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Inducible, Inserted expressed sequence, RMCE-ready) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Col1a1tm9(tetO-Dnmt3b_i1)Jae expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Dnmt3b (MGI:1261819)   Mutation details: RMCE on KH2 cells inserted a cassette that contains a splice acceptor-double polyA sequence and the tetracycline responsive element (tetO) upstream of the DNA methyltransferase 3B gene isoform 1 (Dnmt3b) into the 3'UTR. (J:127808)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	160 strains or lines available

Original:	J:127808 Linhart HG, et al., Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes Dev. 2007 Dec 1;21(23):3110-22
All:	4 reference(s)