Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Capns1tm1.1Otsu Name: calpain, small subunit 1; targeted mutation 1.1, Kinya Otsu MGI ID: MGI:5293309 Synonyms: Capns1flox Gene: Capns1  Location: Chr7:29886361-29898236 bp, - strand  Genetic Position: Chr7, 17.31 cM Alliance: Capns1tm1.1Otsu page

Increased cardiac fibrosis in Capns1tm1.1Otsu/Capns1tm1.1Otsu Tg(Myh6-cre)2182Mds/0 mice after transverse aortic constriction Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:176736
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 7. A floxed neo cassette was inserted downstream of exon 9. Cre-mediated recombination removed the neo cassette and left exons 7 through 9 floxed. (J:176736)

Creation of the conditional Capns1tm1.1Otsu allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Capns1 Mutation:	34 strains or lines available

Original:	J:176736 Taneike M, et al., Calpain protects the heart from hemodynamic stress. J Biol Chem. 2011 Sep 16;286(37):32170-7
All:	1 reference(s)