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Molecular Image Detail
Image
Caption Targeted modification of the Capns1 gene to generate the floxed Capns1tm1.1Otsu allele and the resulting conditional mutant upon removal of the floxed region. A, schematic structures of genomic Capns1 sequences, the targeting construct, the targeted allele, the type II deletion, and the conditional knock-out allele (from top to bottom). The arrowheads represent loxP sites. The targeting construct includes the PGK-neo cassette flanked by loxP sites and a diphtheria toxin gene (DTA). The arrows correspond to the primer sequences for PCR screening.
Copyright This image is from Taneike M, J Biol Chem 2011 Sep 16;286(37):32170-7 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:176736
Associated
Alleles
Symbol Name
Capns1tm1.1Otsu calpain, small subunit 1; targeted mutation 1.1, Kinya Otsu

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory