Summary | Transgene origin | Transgene description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Upk2-cre)1Rkl
Name:	transgene insertion 1, Raghu Kalluri
MGI ID:	MGI:5014304
Synonyms:	UPK II-Cre
Transgene:	Tg(Upk2-cre)1Rkl  Location: unknown
Alliance:	Tg(Upk2-cre)1Rkl page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Upk2-cre)1Rkl expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Upk2 (MGI:98913)   Mutation details: The mouse promoter drives urinary bladder-specific expression of cre with a polyadenylation sequence. A 3.4 kb fragment of the murine Upk2 promoter was cloned in front of cre recombinase and a polyadenylation signal. The construct was used for pronuclear injection of C57BL/6 oocytes. Founder information is not available. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:173505, J:197843)

Activity:	Tissue activity of this recombinase allele
Driver:	Upk2 (mouse) Summary of all recombinase alleles driven by Upk2. Comparative matrix view of recombinase activities Alliance mouse Upk2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:173505 Ayala de la Pena F, et al., Loss of p53 and Acquisition of Angiogenic MicroRNA Profile Are Insufficient to Facilitate Progression of Bladder Urothelial Carcinoma in Situ to Invasive Carcinoma. J Biol Chem. 2011 Jun 10;286(23):20778-87
All:	8 reference(s)