Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ccn2tm1.1Alea
Name:	cellular communication network factor 2; targeted mutation 1.1, Andrew Leask
MGI ID:	MGI:4949916
Synonyms:	CCN2fl, Ctgfflox
Gene:	Ccn2  Location: Chr10:24471340-24474581 bp, + strand  Genetic Position: Chr10, 11.84 cM, cytoband A3-B1
Alliance:	Ccn2tm1.1Alea page

Germline Transmission:	Earliest citation of germline transmission: J:171300
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP iste was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 4. Flp-mediated recombination removed the neo cassette. (J:171300)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccn2 Mutation:	27 strains or lines available

Original:	J:171300 Liu S, et al., CCN2 is required for bleomycin-induced skin fibrosis in mice. Arthritis Rheum. 2011 Jan;63(1):239-46
All:	20 reference(s)