All Phenotypes Ccn2<tm1.1Alea> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ccn2^tm1.1Alea
targeted mutation 1.1, Andrew Leask
MGI:4949916

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ccn2^tm1.1Alea/Ccn2^tm1.1Alea Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA	MGI:5897813
cn2	Ccn2^tm1.1Alea/Ccn2^tm1.1Alea Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:4949922

Allelic Composition	Ccn2^tm1.1Alea/Ccn2^tm1.1Alea Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccn2^tm1.1Alea mutation (1 available); any Ccn2 mutation (27 available)
Mob1a^tm1.1Asuz mutation (0 available); any Mob1a mutation (15 available)
Mob1b^{Gt(CC0690)Wtsi} mutation (0 available); any Mob1b mutation (19 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

abnormal cholangiocyte morphology ( J:228499 )

• increased immature cholangiocyte-like and oval cells as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

increased liver weight ( J:228499 )

• as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

liver fibrosis ( J:228499 )

• as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

endocrine/exocrine glands

abnormal cholangiocyte morphology ( J:228499 )

• increased immature cholangiocyte-like and oval cells as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

growth/size/body

increased liver weight ( J:228499 )

• as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

Allelic Composition	Ccn2^tm1.1Alea/Ccn2^tm1.1Alea Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccn2^tm1.1Alea mutation (1 available); any Ccn2 mutation (27 available)
Tg(Col1a2-cre/ERT,-ALPP)7Cpd mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin physiology ( J:171300 )

• bleomycin-treated mice do not exhibit increased dermal thickness and collagen production unlike in similarly treated wild-type mice

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:171300 )

• bleomycin-treated mice do not exhibit increased dermal thickness and collagen production unlike in similarly treated wild-type mice

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