Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol: Col1a1tm1(tetO-Tcfap2c)Hsc Name: collagen, type I, alpha 1; targeted mutation 1, Hubert Schorle MGI ID: MGI:4949113 Gene: Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D Alliance: Col1a1tm1(tetO-Tcfap2c)Hsc page

Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+ Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+ mice show increased proliferation and induced hepatic steatosis Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:174049
Parent Cell Line:	KH2 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Inducible, Inserted expressed sequence, RMCE-ready) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Col1a1tm1(tetO-Tcfap2c)Hsc expresses 2 genes Knock-in expresses: Organism Expressed Gene Note mouse Tfap2c (MGI:106032) mouse Tfap2c (MGI:106032)   Mutation details: RMCE on KH2 cells inserted a cassette that contains a tetracycline responsive element (TRE or tetO) and mouse AP-2gamma (Tcfap2c) cDNA sequence into the 3'UTR. With doxycycline treatment, Tcfap2c expression from the Col1a1 locus is widespread with high levels in skin, intestine and stomach, while lower levels are seen in the heart, spleen, thymus and several other organs. No expression is seen in the brain or testes. (J:174049)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	160 strains or lines available

Original:	J:174049 Holl D, et al., Transgenic Overexpression of Tcfap2c/AP-2gamma Results in Liver Failure and Intestinal Dysplasia. PLoS One. 2011;6(7):e22034
All:	1 reference(s)