Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rims2tm1Sse
Name:	regulating synaptic membrane exocytosis 2; targeted mutation 1, Susumu Seino
MGI ID:	MGI:4838195
Synonyms:	Rim2alpha-
Gene:	Rims2  Location: Chr15:39061681-39547768 bp, + strand  Genetic Position: Chr15, 15.45 cM, cytoband C
Alliance:	Rims2tm1Sse page

Germline Transmission:	Earliest citation of germline transmission: J:163080
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 4 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on islet cell extracts. (J:163080)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rims2 Mutation:	250 strains or lines available

Original:	J:163080 Yasuda T, et al., Rim2alpha determines docking and priming States in insulin granule exocytosis. Cell Metab. 2010 Aug 4;12(2):117-29
All:	1 reference(s)