Phenotypes associated with this allele

• Allele Symbol: Rims2^tm1Sse
• Allele Name: targeted mutation 1, Susumu Seino
• Allele ID: MGI:4838195
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rims2^tm1Sse/Rims2^tm1Sse	B6.Cg-Rims2^tm1Sse	MGI:4838197

Genotype
MGI:4838197

hm1

• Allelic Composition: Rims2^tm1Sse/Rims2^tm1Sse
• Genetic Background: B6.Cg-Rims2^tm1Sse

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:163080 )

• despite a 1.4-fold increase in insulin content, islets exhibit reduced insulin secretion compared with wild-type cells

• GIP (gastric inhibitory polypeptide)- and 8-bromo-cAMP-potentiated insulin secretion is reduced compared to in similarly treated wild-type cells

decreased circulating glucose level ( J:163080 )

• in fasting mice

increased circulating glucose level ( J:163080 )

• following glucose administration

decreased circulating adrenaline level ( J:163080 )

• following insulin administration

increased circulating glucagon level ( J:163080 )

• following insulin administration

decreased circulating insulin level ( J:163080 )

• following glucose administration

decreased circulating insulin-like growth factor I level ( J:163080 )

decreased circulating growth hormone level ( J:163080 )

• basal and hypoglycemia-induced

impaired glucose tolerance ( J:163080 )

endocrine/exocrine glands

increased pancreatic alpha cell number ( J:163080 )

pancreatic islet hyperplasia ( J:163080 )

abnormal pancreatic beta cell physiology ( J:163080 )

• beta cells contain fewer docked insulin granules than in wild-type cells

• insulin granule fusion events caused by potassium ion stimulation are decreased compared to in similarly treated wild-type cells

• beta cells fail to exhibit voltage dependent inactivation of voltage-dependent calcium ion channel currents unlike wild-type mice

decreased insulin secretion ( J:163080 )

• despite a 1.4-fold increase in insulin content, islets exhibit reduced insulin secretion compared with wild-type cells

• GIP (gastric inhibitory polypeptide)- and 8-bromo-cAMP-potentiated insulin secretion is reduced compared to in similarly treated wild-type cells

growth/size/body

decreased body size ( J:163080 )