Gt(ROSA)26Sortm1(NOTCH3)Sat
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm1(NOTCH3)Sat |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Spyros Artavanis-Tsakonas |
MGI ID: |
MGI:4830990 |
Synonyms: |
WT76 |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm1(NOTCH3)Sat page
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Germline Transmission: |
Earliest citation of germline transmission:
J:133358
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Parent Cell Line: |
W4 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm1(NOTCH3)Sat expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
NOTCH3 (4854) |
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Mutation details: A targeting vector containing a splice acceptor site, a loxP-flanked PGK neomycin cassette, a human NOTCH3 cDNA and an IRES-nuclear GFP sequence was inserted into the GT(ROSA)26Sor locus.
(J:133358)
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Schematic of the Gt(ROSA)26Sortm1(NOTCH3)Sat, Gt(ROSA)26Sortm2(NOTCH3*C455R)Sat and Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat constructs |
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:133358 Arboleda-Velasquez JF, et al., Linking Notch signaling to ischemic stroke. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4856-61 |
All: |
4 reference(s) |
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