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Trac Gene Detail
Summary
  • Symbol
    Trac
  • Name
    T cell receptor alpha constant
  • Synonyms
    Gm16914
  • Feature Type
    gene segment
  • IDs
    MGI:4439838
    NCBI Gene: 100101484
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:54457978-54461655 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 27.70 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_4439838
 gene segment Chr14:54457978-54461663 (+)
129S1/SvImJ MGP_129S1SvImJ_G0002422
 gene segment Chr14:48148844-48152520 (+)
A/J MGP_AJ_G0002397
 gene segment Chr14:47240801-47244477 (+)
AKR/J MGP_AKRJ_G0002383
 gene segment Chr14:48949783-48953459 (+)
BALB/cJ MGP_BALBcJ_G0002392
 gene segment Chr14:47209574-47216213 (+)
C3H/HeJ MGP_C3HHeJ_G0002370
 gene segment Chr14:48630908-48634692 (+)
C57BL/6NJ MGP_C57BL6NJ_G0002518
 gene segment Chr14:50616802-50622093 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0002120
 gene segment Chr14:45653430-45657119 (+)
CAST/EiJ MGP_CASTEiJ_G0002332
 gene segment Chr14:44862756-44866430 (+)
CBA/J MGP_CBAJ_G0002362
 gene segment Chr14:52108479-52112158 (+)
DBA/2J MGP_DBA2J_G0002368
 gene segment Chr14:46985030-46988741 (+)
FVB/NJ MGP_FVBNJ_G0002380
 gene segment Chr14:46439267-46443264 (+)
LP/J MGP_LPJ_G0002422
 gene segment Chr14:49180064-49183835 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0002350
 gene segment Chr14:51549958-51554023 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0002512
 gene segment Chr14:48131550-48135225 (+)
PWK/PhJ MGP_PWKPhJ_G0002293
 gene segment Chr14:43508755-43513087 (+)
SPRET/EiJ MGP_SPRETEiJ_G0002246
 gene segment Chr14:44109901-44115269 (+)
WSB/EiJ MGP_WSBEiJ_G0002362
 gene segment Chr14:48423310-48428096 (+)



Homology
more
  • Human Ortholog
    TRA, T cell receptor alpha locus
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRA, T cell receptor alpha locus
  • Synonyms
    IMD7, TCRA, TRA@
  • Links
    NCBI Gene ID: 6955
    UniProt: P0DSE1, P0DTU3

  • Chr Location
    14q11.2; chr14:21621904-22552132 (+)  GRCh38
  • Human Ortholog
    TRAC, T cell receptor alpha constant
  • Synonyms
    IMD7, TCRA, TRA, TRCA
  • Links
    NCBI Gene ID: 28755
    UniProt: P01848

  • Chr Location
    14q11.2; chr14:22547506-22552156 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TRAC associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    8
  • Endonuclease-mediated
    2
  • Gene trapped
    2
  • Targeted
    1
  • Transgenic
    3
  • Genomic Mutations
    1 involving Trac
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    5 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    46
  • cDNA Data
    5
  • Literature Summary
    3
Sequences &
Gene Models
less
  • All Sequences
    26
  • RefSeq
    1
  • UniProt
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic 100101484 NCBI Gene Model | MGI Sequence Detail 3678 C57BL/6J ±  kb
polypeptide A0A991BQX6 UniProt | EBI | MGI Sequence Detail 137 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR015370 T-cell receptor alpha chain, constant domain
Molecular
Reagents
less
  • All nucleic 93
    Genomic 27
    cDNA 61
    Primer pair 1
    Other 4
Other
Accession IDs
less
MGD-MRK-14846, MGI:98554
References
more
  • Summaries
    All 53
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:7626 Chien Y, et al., A third type of murine T-cell receptor gene. Nature. 1984 Nov 1-7;312(5989):31-5
  • Latest
    J:337059 Iwanami N, et al., Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR alpha chain of iNKT cells. Nat Commun. 2023 Jun 20;14(1):3645
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory