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Defb28 Gene Detail
Summary
  • Symbol
    Defb28
  • Name
    defensin beta 28
  • Synonyms
    OTTMUSG00000015852
  • Feature Type
    protein coding gene
  • IDs
    MGI:3650536
    NCBI Gene: 545475
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152360175-152363367 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 75.20 cM
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3650536
 protein coding gene Chr2:152360175-152363367 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026665
 protein coding gene Chr2:157080783-157083971 (+)
A/J MGP_AJ_G0026631
 protein coding gene Chr2:150806051-150809237 (+)
AKR/J MGP_AKRJ_G0026601
 protein coding gene Chr2:155212503-155215695 (+)
BALB/cJ MGP_BALBcJ_G0026640
 protein coding gene Chr2:151116447-151119639 (+)
C3H/HeJ MGP_C3HHeJ_G0026383
 protein coding gene Chr2:155591838-155595030 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027089
 protein coding gene Chr2:161649437-161652629 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024460
 protein coding gene Chr2:144396292-144399585 (+)
CAST/EiJ MGP_CASTEiJ_G0025844
 protein coding gene Chr2:155834165-155837353 (+)
CBA/J MGP_CBAJ_G0026361
 protein coding gene Chr2:167574777-167577969 (+)
DBA/2J MGP_DBA2J_G0026497
 protein coding gene Chr2:150021234-150024426 (+)
FVB/NJ MGP_FVBNJ_G0026463
 protein coding gene Chr2:148472957-148476149 (+)
LP/J MGP_LPJ_G0026601
 protein coding gene Chr2:157226231-157229419 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026484
 protein coding gene Chr2:171682648-171685834 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027145
 protein coding gene Chr2:155093793-155096985 (+)
PWK/PhJ MGP_PWKPhJ_G0025578
 protein coding gene Chr2:149540447-149543705 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025381
 protein coding gene Chr2:153931748-153934933 (+)
WSB/EiJ MGP_WSBEiJ_G0025914
 protein coding gene Chr2:156011457-156014645 (+)



Homology
more
  • Human Ortholog
    DEFB115, defensin beta 115
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFB115, defensin beta 115
  • Synonyms
    DEFB-15
  • Links
    NCBI Gene ID: 245929
    neXtProt AC: NX_Q30KQ5
    UniProt: Q30KQ5

  • Chr Location
    20q11.21; chr20:31257664-31259632 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Defb28
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    6 strains or lines available
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

Cellular Component
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 545475 NCBI Gene Model | MGI Sequence Detail 3193 C57BL/6J ±  kb
transcript NM_001037502 RefSeq | MGI Sequence Detail 397 C57BL/6  
polypeptide NP_001032591 RefSeq | MGI Sequence Detail 89 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR025933 Beta-defensin
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 1
References
more
  • Summaries
    All 16
    Phenotypes 5
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory