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Skint2 Gene Detail
Summary
  • Symbol
    Skint2
  • Name
    selection and upkeep of intraepithelial T cells 2
  • Synonyms
    B7S3, OTTMUSG00000008540
  • Feature Type
    protein coding gene
  • IDs
    MGI:3649629
    NCBI Gene: 329919
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr4:112470795-112509445 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 51.53 cM
Strain
Comparison
more
  • SNPs within 2kb
    696 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3649629
 protein coding gene Chr4:112414391-112509445 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028584
 protein coding gene Chr4:112976444-113009223 (+)
A/J MGP_AJ_G0028547
 protein coding gene Chr4:108879383-108919932 (+)
AKR/J MGP_AKRJ_G0028494
 protein coding gene Chr4:111605112-111645999 (+)
BALB/cJ MGP_BALBcJ_G0028566
 protein coding gene Chr4:109591193-109625274 (+)
C3H/HeJ MGP_C3HHeJ_G0028280
 protein coding gene Chr4:112829740-112871788 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029009
 protein coding gene Chr4:117536862-117642234 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026297
 protein coding gene Chr4:104091976-104128485 (+)
CAST/EiJ MGP_CASTEiJ_G0027717
 protein coding gene Chr4:110203045-110235783 (+)
CBA/J MGP_CBAJ_G0028249
 protein coding gene Chr4:120867379-120910180 (+)
DBA/2J MGP_DBA2J_G0028397
 protein coding gene Chr4:109090817-109126829 (+)
FVB/NJ MGP_FVBNJ_G0028365
 protein coding gene Chr4:107847809-107889544 (+)
LP/J MGP_LPJ_G0028498
 protein coding gene Chr4:113246195-113290260 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028391
 protein coding gene Chr4:126284388-126354717 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029045
 protein coding gene Chr4:112288355-112375271 (+)
PWK/PhJ MGP_PWKPhJ_G0027442
 protein coding gene Chr4:106781537-106821271 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027266
 protein coding gene Chr4:109222348-109254661 (+)
WSB/EiJ MGP_WSBEiJ_G0027797
 protein coding gene Chr4:112093051-112124423 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased dendritic epidermal T cell numbers in the skin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    14
  • cDNA Data
    4
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 329919 NCBI Gene Model | MGI Sequence Detail 38651 C57BL/6J ±  kb
transcript NM_001285965 RefSeq | MGI Sequence Detail 1299 C57BL/6  
polypeptide A7XUX6 UniProt | EBI | MGI Sequence Detail 400 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 5
    cDNA 4
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 25
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
  • Latest
    J:323863 McKenzie DR, et al., Normality sensing licenses local T cells for innate-like tissue surveillance. Nat Immunol. 2022 Mar;23(3):411-422
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory