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Ces1a Gene Detail
Summary
  • Symbol
    Ces1a
  • Name
    carboxylesterase 1A
  • Synonyms
    Gm4976
  • Feature Type
    protein coding gene
  • IDs
    MGI:3648919
    NCBI Gene: 244595
  • Member of
    Ces1 cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:93746842-93774820 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 44.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    441 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3648919
 protein coding gene Chr8:93746842-93774820 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033940
 protein coding gene Chr8:94344830-94371669 (-)
A/J MGP_AJ_G0033923
 protein coding gene Chr8:90627949-90654896 (-)
AKR/J MGP_AKRJ_G0033849
 protein coding gene Chr8:93174016-93200856 (-)
BALB/cJ MGP_BALBcJ_G0033915
 protein coding gene Chr8:90782555-90809391 (-)
C3H/HeJ MGP_C3HHeJ_G0033625
 protein coding gene Chr8:93890494-93917332 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034436
 protein coding gene Chr8:97813239-97842020 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031377
 protein coding gene Chr8:84552567-84580028 (-)
CAST/EiJ MGP_CASTEiJ_G0032957
 protein coding gene Chr8:93451751-93479964 (-)
CBA/J MGP_CBAJ_G0033601
 protein coding gene Chr8:101068543-101095376 (-)
DBA/2J MGP_DBA2J_G0033755
 protein coding gene Chr8:90168116-90195213 (-)
FVB/NJ MGP_FVBNJ_G0033702
 protein coding gene Chr8:89108082-89134903 (-)
LP/J MGP_LPJ_G0033847
 protein coding gene Chr8:94464555-94491439 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033744
 protein coding gene Chr8:103417535-103444277 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034454
 protein coding gene Chr8:93291958-93318790 (-)
PWK/PhJ MGP_PWKPhJ_G0032659
 protein coding gene Chr8:89516909-89545089 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032496
 protein coding gene Chr8:92142544-92172071 (-)
WSB/EiJ MGP_WSBEiJ_G0033069
 protein coding gene Chr8:93750142-93777737 (-)



Homology
more
  • Human Ortholog
    CES1, carboxylesterase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CES1, carboxylesterase 1
  • Synonyms
    ACAT, CE-1, CEH, CES2, hCE-1, HMSE, HMSE1, PCE-1, REH, SES1, TGH
  • Links
    NCBI Gene ID: 1066
    neXtProt AC: NX_P23141
    UniProt: P23141

  • Chr Location
    16q12.2; chr16:55802851-55833337 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CES1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    2
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 244595 NCBI Gene Model | MGI Sequence Detail 27979 C57BL/6J ±  kb
transcript NM_001013764 RefSeq | MGI Sequence Detail 1980 C57BL/6  
polypeptide NP_001013786 RefSeq | MGI Sequence Detail 563 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 1
References
more
  • Summaries
    All 19
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:164863 Holmes RS, et al., Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Mamm Genome. 2010 Oct;21(9-10):427-41
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory