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Zfp541 Gene Detail
Summary
  • Symbol
    Zfp541
  • Name
    zinc finger protein 541
  • Synonyms
    EG666528
  • Feature Type
    protein coding gene
  • IDs
    MGI:3647699
    NCBI Gene: 666528
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:15795739-15830259 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 8.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    694 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3647699
 protein coding gene Chr7:15795700-15830265 (+)
129S1/SvImJ ENSMUSG00200039374
 protein coding gene Chr7:9170475-9204879 (+)
A/J ENSMUSG00195047511
 protein coding gene Chr7:9631901-9666325 (+)
AKR/J ENSMUSG00220026042
 protein coding gene Chr7:7924096-7958499 (+)
BALB/cJ ENSMUSG00180048736
 protein coding gene Chr7:9547689-9582113 (+)
C3H/HeJ ENSMUSG00175046653
 protein coding gene Chr7:10035158-10069560 (+)
C57BL/6NJ ENSMUSG00215038743
 protein coding gene Chr7:9294393-9328916 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029221
 protein coding gene Chr7:15089054-15114089 (+)
CAST/EiJ ENSTCUG00005052003
 protein coding gene Chr7:10039863-10074437 (+)
CBA/J ENSMUSG00210044455
 protein coding gene Chr7:9262540-9296944 (+)
DBA/2J ENSMUSG00185052511
 protein coding gene Chr7:12777015-12811417 (+)
FVB/NJ ENSMUSG00205021746
 protein coding gene Chr7:9668863-9703261 (+)
JF1/MsJ ENSUMUG00000033621
 protein coding gene Chr7:16047573-16082380 (+)
LP/J ENSMUSG00230041534
 protein coding gene Chr7:16994905-17029306 (+)
NOD/ShiLtJ ENSMUSG00190029836
 protein coding gene Chr7:6096399-6130910 (+)
NZO/HlLtJ ENSMUSG00225053014
 protein coding gene Chr7:14229354-14263749 (+)
PWK/PhJ ENSLUMG00010049403
 protein coding gene Chr7:12353774-12388283 (+)
SPRET/EiJ ENSMSPG00010041996
 protein coding gene Chr7:8814805-8848297 (+)
WSB/EiJ ENSIUOG00005051551
 protein coding gene Chr7:16408444-16442953 (-)



Homology
more
  • Human Ortholog
    ZNF541, zinc finger protein 541
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF541, zinc finger protein 541
  • Links
    NCBI Gene ID: 84215
    UniProt: Q9H0D2

  • Chr Location
    19q13.33; chr19:47520690-47573309 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Knock-out males are infertile, with delayed progression from early to mid/late pachynema and no mature spermatozoa in the cauda epididymis. Spermatocytes show abnormal programmed DNA double-strand break repair, impaired crossover formation and resolution, and asynapsis of the XY chromosomes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    622
  • Tissues
    16
  • cDNA Data
    3
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000078796 Ensembl Gene Model | MGI Sequence Detail 34521 C57BL/6J ±  kb
    transcript ENSMUST00000209369 Ensembl | MGI Sequence Detail 4879 Not Applicable  
    polypeptide ENSMUSP00000147475 Ensembl | MGI Sequence Detail 1363 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 3
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory