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Spink14 Gene Detail
Summary
  • Symbol
    Spink14
  • Name
    serine peptidase inhibitor, Kazal type 14
  • Synonyms
    Gm5505
  • Feature Type
    protein coding gene
  • IDs
    MGI:3646952
    NCBI Gene: 433178
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr18:44160936-44165275 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 23.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    104 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3646952
 protein coding gene Chr18:44160936-44165484 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024391
 protein coding gene Chr18:42765864-42770193 (+)
A/J MGP_AJ_G0024358
 protein coding gene Chr18:41256933-41261247 (+)
AKR/J MGP_AKRJ_G0024327
 protein coding gene Chr18:42412952-42417265 (+)
BALB/cJ MGP_BALBcJ_G0024358
 protein coding gene Chr18:41336354-41340695 (+)
C3H/HeJ MGP_C3HHeJ_G0024125
 protein coding gene Chr18:42441021-42446398 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024802
 protein coding gene Chr18:44261741-44266057 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022238
 protein coding gene Chr18:41045238-41049650 (+)
CAST/EiJ MGP_CASTEiJ_G0023599
 protein coding gene Chr18:42429118-42433458 (+)
CBA/J MGP_CBAJ_G0024094
 protein coding gene Chr18:45455013-45459353 (+)
DBA/2J MGP_DBA2J_G0024224
 protein coding gene Chr18:40852649-40856963 (+)
FVB/NJ MGP_FVBNJ_G0024190
 protein coding gene Chr18:40457459-40461788 (+)
LP/J MGP_LPJ_G0024308
 protein coding gene Chr18:42794884-42799213 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024221
 protein coding gene Chr18:46813839-46818162 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024849
 protein coding gene Chr18:42276347-42280686 (+)
PWK/PhJ MGP_PWKPhJ_G0023343
 protein coding gene Chr18:41062842-41067261 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023148
 protein coding gene Chr18:42513230-42517550 (+)
WSB/EiJ MGP_WSBEiJ_G0023662
 protein coding gene Chr18:42192779-42197106 (+)



Homology
more
  • Human Ortholog
    SPINK14, serine peptidase inhibitor Kazal type 14 (putative)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPINK14, serine peptidase inhibitor Kazal type 14 (putative)
  • Synonyms
    SPINK5L2
  • Links
    NCBI Gene ID: 408187
    neXtProt AC: NX_Q6IE38
    UniProt: Q6IE38

  • Chr Location
    chr5:148168546-148175619 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 433178 NCBI Gene Model | MGI Sequence Detail 4340 C57BL/6J ±  kb
    transcript NM_001039218 RefSeq | MGI Sequence Detail 566 C57BL/6  
    polypeptide NP_001034307 RefSeq | MGI Sequence Detail 96 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR002350 Kazal domain
      IPR036058 Kazal domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 1
      cDNA 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 15
      Phenotypes 4
    • Earliest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
    • Latest
      J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory