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Eif4a3l1 Gene Detail
Summary
  • Symbol
    Eif4a3l1
  • Name
    eukaryotic translation initiation factor 4A3 like 1
  • Synonyms
    B020013A22Rik, Gm8994
  • Feature Type
    protein coding gene
  • IDs
    MGI:3644226
    NCBI Gene: 668137
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:136304537-136306981 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 66.54 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    238 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3644226
 protein coding gene Chr6:136304537-136306981 (+)
129S1/SvImJ ENSMUSG00200029755
 protein coding gene Chr6:133811805-133822754 (+)
A/J ENSMUSG00195007467
 protein coding gene Chr6:132673077-132674533 (+)
A/J ENSMUSG00195007502
 protein coding gene Chr6:132663579-132666020 (+)
AKR/J ENSMUSG00220033135
 protein coding gene Chr6:130891628-130894069 (+)
AKR/J ENSMUSG00220032758
 protein coding gene Chr6:130901126-130902582 (+)
BALB/cJ ENSMUSG00180015291
 protein coding gene Chr6:132768378-132770821 (+)
C3H/HeJ ENSMUSG00175032259
 protein coding gene Chr6:132692298-132694740 (+)
C57BL/6NJ ENSMUSG00215022948
 protein coding gene Chr6:132928368-132930813 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005034600
 protein coding gene Chr6:133607600-133608961 (+)
CBA/J ENSMUSG00210003917
 protein coding gene Chr6:132744628-132747070 (+)
DBA/2J ENSMUSG00185021288
 protein coding gene Chr6:133407905-133409361 (+)
DBA/2J ENSMUSG00185021033
 protein coding gene Chr6:133398407-133400848 (+)
FVB/NJ ENSMUSG00205025249
 protein coding gene Chr6:131854308-131868164 (+)
JF1/MsJ no annotation
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190006309
 protein coding gene Chr6:133246125-133247581 (+)
NOD/ShiLtJ ENSMUSG00190006303
 protein coding gene Chr6:133236625-133239068 (+)
NZO/HlLtJ ENSMUSG00225006935
 protein coding gene Chr6:137453398-137455843 (+)
PWK/PhJ ENSLUMG00010040882
 protein coding gene Chr6:131203202-131205640 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005019916
 protein coding gene Chr6:133497089-133498450 (+)



Homology
more
  • Human Ortholog
    EIF4A3, eukaryotic translation initiation factor 4A3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF4A3, eukaryotic translation initiation factor 4A3
  • Synonyms
    DDX48, eIF-4A-III, eIF4A-III, eIF4AIII, Fal1, MUK34, NMP265, NUK34, RCPS
  • Links
    NCBI Gene ID: 9775
    UniProt: P38919

  • Chr Location
    17q25.3; chr17:80134369-80147151 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EIF4A3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 668137 NCBI Gene Model | MGI Sequence Detail 2445 C57BL/6J ±  kb
transcript NM_001142734 RefSeq | MGI Sequence Detail 1573 C57BL/6  
polypeptide NP_001136206 RefSeq | MGI Sequence Detail 411 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • EC
    3.6.4.13
  • InterPro Domains
    IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    IPR011545 DEAD/DEAH-box helicase domain
    IPR001650 Helicase, C-terminal domain-like
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
  • GlyGen
    E9PV04 1 site
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 1
Other
Accession IDs
less
MGI:3809663, MGI:6330775
References
more
  • Summaries
    All 20
    Gene Ontology 9
  • Earliest
    J:23000 MGD Nomenclature Committee, Nomenclature Committee Use. 1995-02-14;
  • Latest
    J:389486 Mouse Genome Informatics and Ensembl Genome Database Project, MGI Strain Genome Feature and Gene Model Load from Ensembl. Database Release. 2026;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory