Ms4a4a MGI Mouse Gene Detail - MGI:3643932 - membrane-spanning 4-domains, subfamily A, member 4A

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Ms4a4a Gene Detail

Symbol

Ms4a4a
Name

membrane-spanning 4-domains, subfamily A, member 4A
Synonyms

EG666907

Feature Type

protein coding gene
IDs

MGI:3643932
NCBI Gene: 666907
Member of

Ms4ac cluster
Alliance

gene page
Transcription Start Sites

29 TSS

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Sequence Map

Chr19:11352887-11370154 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 8.44 cM
Mapping Data

1 experiment

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SNPs within 2kb

100 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_3643932	protein coding gene	Chr19:11352827-11370682 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024877	protein coding gene	Chr19:8757273-8782621 (+)
A/J	MGP_AJ_G0024845	protein coding gene	Chr19:8195380-8217976 (+)
AKR/J	MGP_AKRJ_G0024820	protein coding gene	Chr19:8505632-8524316 (+)
BALB/cJ	MGP_BALBcJ_G0024845	protein coding gene	Chr19:8231840-8249046 (+)
C3H/HeJ	MGP_C3HHeJ_G0024611	protein coding gene	Chr19:8391025-8409612 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025293	protein coding gene	Chr19:9155879-9175282 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022720	protein coding gene	Chr19:8595777-8614062 (+)
CAST/EiJ	MGP_CASTEiJ_G0024084	protein coding gene	Chr19:8025797-8051515 (+)
CBA/J	MGP_CBAJ_G0024585	protein coding gene	Chr19:9215392-9242435 (+)
DBA/2J	MGP_DBA2J_G0024712	protein coding gene	Chr19:8186309-8204764 (+)
FVB/NJ	MGP_FVBNJ_G0024679	protein coding gene	Chr19:8212281-8231474 (+)
LP/J	MGP_LPJ_G0024799	protein coding gene	Chr19:8724985-8742301 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024706	protein coding gene	Chr19:9099079-9118268 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025341	protein coding gene	Chr19:8533767-8551537 (+)
PWK/PhJ	MGP_PWKPhJ_G0023828	protein coding gene	Chr19:7634121-7652744 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023634	protein coding gene	Chr19:7710440-7727755 (+)
WSB/EiJ	MGP_WSBEiJ_G0024146	protein coding gene	Chr19:8428153-8446853 (+)

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Human Ortholog

MS4A4A, membrane spanning 4-domains A4A

Vertebrate Orthologs

20

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MS4A4A, membrane spanning 4-domains A4A
Synonyms

4SPAN1, CD20L1, CD20-L1, HDCME31P, MS4A4, MS4A7
Links

HGNC:13371

NCBI Gene ID: 51338

neXtProt AC: NX_Q96JQ5

UniProt: Q96JQ5
Chr Location

11q12.2; chr11:60185657-60318080 (+) GRCh38

Human Ortholog

MS4A4E, membrane spanning 4-domains A4E
Links

HGNC:14284

NCBI Gene ID: 643680

UniProt: Q96PG1
Chr Location

11q12.2; chr11:60200270-60243137 (-) GRCh38

MGI Vertebrate Homology

Ms4a4a stringent orthology
2 human;1 mouse;1 rat;17 zebrafish
HCOP

vertebrate homology predictions: MS4A4A, MS4A4E
Gene Tree

Ms4a4a

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
4 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show abnormal macrophage physiology and impaired eosinophil infiltration during lung allergic inflammation induced by intranasal administration of house dust mite.

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All GO Annotations

6
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

27
RefSeq

4
UniProt

1
CCDS

CCDS79692.1

Ensembl

ENSMUSG00000101389 (Evidence)
NCBI Gene

666907

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000101389	Ensembl Gene Model \| MGI Sequence Detail	17268	C57BL/6J	± kb
	transcript	ENSMUST00000188995	Ensembl \| MGI Sequence Detail	836	Not Applicable
	polypeptide	ENSMUSP00000140768	Ensembl \| MGI Sequence Detail	236	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR007237 CD20-like family

IPR030417 Membrane-spanning 4-domains subfamily A

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Summaries

All 14

Gene Ontology 2

Phenotypes 4
Earliest

J:305894 Mattiola I, et al., The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell-mediated resistance to metastasis. Nat Immunol. 2019 Aug;20(8):1012-1022
Latest

J:296429 Sui Y, et al., MS4A4A Regulates Arginase 1 Induction during Macrophage Polarization and Lung Inflammation in Mice. Eur J Immunol. 2020 Oct;50(10):1602-1605

TSS for Ms4a4a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155167	Chr19:11352822-11352835 (+)	-58 bp
Tssr155168	Chr19:11352852-11352892 (+)	-15 bp
Tssr155169	Chr19:11352901-11352918 (+)	23 bp
Tssr155170	Chr19:11352930-11352944 (+)	50 bp
Tssr155171	Chr19:11352945-11352956 (+)	64 bp
Tssr155172	Chr19:11352960-11352971 (+)	79 bp
Tssr155173	Chr19:11354470-11354483 (+)	1,590 bp
Tssr155174	Chr19:11356517-11356530 (+)	3,637 bp
Tssr155175	Chr19:11358242-11358260 (+)	5,364 bp
Tssr155176	Chr19:11359177-11359191 (+)	6,297 bp
Tssr155177	Chr19:11359256-11359291 (+)	6,387 bp
Tssr155178	Chr19:11359334-11359357 (+)	6,459 bp
Tssr155179	Chr19:11359925-11359937 (+)	7,044 bp
Tssr155180	Chr19:11360942-11360946 (+)	8,057 bp
Tssr155181	Chr19:11363840-11363851 (+)	10,959 bp
Tssr155182	Chr19:11363975-11363987 (+)	11,094 bp
Tssr155183	Chr19:11364091-11364105 (+)	11,211 bp
Tssr155184	Chr19:11364146-11364163 (+)	11,268 bp
Tssr155185	Chr19:11364185-11364198 (+)	11,305 bp
Tssr155186	Chr19:11364229-11364240 (+)	11,348 bp
Tssr155187	Chr19:11364859-11364879 (+)	11,982 bp
Tssr155188	Chr19:11364994-11365008 (+)	12,114 bp
Tssr155189	Chr19:11365185-11365198 (+)	12,305 bp
Tssr155190	Chr19:11365590-11365733 (+)	12,775 bp
Tssr155191	Chr19:11366537-11366545 (+)	13,654 bp
Tssr155192	Chr19:11366554-11366593 (+)	13,687 bp
Tssr155193	Chr19:11367625-11367634 (+)	14,743 bp
Tssr155194	Chr19:11367646-11367686 (+)	14,779 bp
Tssr155195	Chr19:11367690-11367711 (+)	14,814 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23