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Gpr52 Gene Detail
Summary
  • Symbol
    Gpr52
  • Name
    G protein-coupled receptor 52
  • Synonyms
    EG620246
  • Feature Type
    protein coding gene
  • IDs
    MGI:3643278
    NCBI Gene: 620246
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:160403908-160405544 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 69.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3643278
 protein coding gene Chr1:160402287-160407274 (-)
129S1/SvImJ ENSMUSG00200005330
 protein coding gene Chr1:157894263-157895899 (-)
A/J ENSMUSG00195021456
 protein coding gene Chr1:157229532-157231168 (-)
AKR/J ENSMUSG00220012682
 protein coding gene Chr1:157014180-157015816 (-)
BALB/cJ ENSMUSG00180032943
 protein coding gene Chr1:157451625-157453261 (-)
C3H/HeJ ENSMUSG00175037411
 protein coding gene Chr1:157529446-157531082 (-)
C57BL/6NJ ENSMUSG00215035892
 protein coding gene Chr1:157422412-157424048 (-)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005018995
 protein coding gene Chr1:156061191-156062827 (-)
CBA/J ENSMUSG00210020664
 protein coding gene Chr1:157427284-157428920 (-)
DBA/2J ENSMUSG00185043666
 protein coding gene Chr1:161672911-161674547 (-)
FVB/NJ ENSMUSG00205010043
 protein coding gene Chr1:156516647-156518283 (-)
JF1/MsJ ENSUMUG00000019525
 protein coding gene Chr1:160834047-160835683 (-)
LP/J ENSMUSG00230014307
 protein coding gene Chr1:161295678-161297314 (-)
NOD/ShiLtJ ENSMUSG00190028403
 protein coding gene Chr1:157261061-157262697 (-)
NZO/HlLtJ ENSMUSG00225003976
 protein coding gene Chr1:164912031-164913667 (-)
PWK/PhJ ENSLUMG00010040885
 protein coding gene Chr1:156218907-156220543 (-)
SPRET/EiJ ENSMSPG00010039852
 protein coding gene Chr1:159620767-159622403 (-)
WSB/EiJ ENSIUOG00005014902
 protein coding gene Chr1:156825696-156827332 (-)



Homology
more
  • Human Ortholog
    GPR52, G protein-coupled receptor 52
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR52, G protein-coupled receptor 52
  • Links
    NCBI Gene ID: 9293
    UniProt: Q9Y2T5

  • Chr Location
    1q25.1; chr1:174447964-174449545 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased anxiety response in an open field test and increased startle response when treated with MK-801.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000118401 Ensembl Gene Model | MGI Sequence Detail 1637 C57BL/6J ±  kb
transcript ENSMUST00000238289 Ensembl | MGI Sequence Detail 1637 Not Applicable  
polypeptide ENSMUSP00000158769 Ensembl | MGI Sequence Detail 361 Not Applicable  
For the selected sequence
Protein
Information
less
References
more
  • Summaries
    All 22
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:214470 Komatsu H, et al., Anatomical transcriptome of G protein-coupled receptors leads to the identification of a novel therapeutic candidate GPR52 for psychiatric disorders. PLoS One. 2014;9(2):e90134
  • Latest
    J:336265 Krieg PF, et al., GPR52 regulates cAMP in T cells but is dispensable for encephalitogenic responses. Front Immunol. 2022;13:1113348
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory