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Hottip Gene Detail
Summary
  • Symbol
    Hottip
  • Name
    Hoxa distal transcript antisense RNA
  • Synonyms
    ENSMUSG00000055408, Gm15053
  • Feature Type
    lncRNA gene
  • IDs
    MGI:3642509
    NCBI Gene: 791364
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr6:52239760-52244588 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 25.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    18 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3642509
 lncRNA gene Chr6:52239760-52244588 (+)
129S1/SvImJ MGP_129S1SvImJ_G0006964
 lincRNA gene Chr6:51507939-51512767 (+)
A/J MGP_AJ_G0006959
 lincRNA gene Chr6:49098605-49103439 (+)
AKR/J MGP_AKRJ_G0006929
 lincRNA gene Chr6:50804888-50809718 (+)
BALB/cJ MGP_BALBcJ_G0006936
 lincRNA gene Chr6:49460982-49465818 (+)
C3H/HeJ MGP_C3HHeJ_G0006880
 lincRNA gene Chr6:50816345-50821171 (+)
C57BL/6NJ MGP_C57BL6NJ_G0007098
 lincRNA gene Chr6:52646397-52651213 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0006345
 lincRNA gene Chr6:46746141-46750920 (+)
CAST/EiJ MGP_CASTEiJ_G0006796
 lincRNA gene Chr6:50631827-50636589 (+)
CBA/J MGP_CBAJ_G0006862
 lincRNA gene Chr6:54857903-54862729 (+)
DBA/2J MGP_DBA2J_G0006882
 lincRNA gene Chr6:49021396-49026222 (+)
FVB/NJ MGP_FVBNJ_G0006905
 lincRNA gene Chr6:48632482-48638885 (+)
LP/J MGP_LPJ_G0006964
 lincRNA gene Chr6:51484292-51489118 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0006885
 lincRNA gene Chr6:57472443-57477270 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0007102
 lincRNA gene Chr6:50744011-50748837 (+)
PWK/PhJ MGP_PWKPhJ_G0006736
 lincRNA gene Chr6:48646198-48651024 (+)
SPRET/EiJ MGP_SPRETEiJ_G0006646
 lincRNA gene Chr6:50071999-50076798 (+)
WSB/EiJ MGP_WSBEiJ_G0006851
 lincRNA gene Chr6:50752225-50757050 (+)



Homology
more
  • Human Ortholog
    HOTTIP, HOXA distal transcript antisense RNA
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOTTIP, HOXA distal transcript antisense RNA
  • Synonyms
    HOXA13-AS1, HOXA-AS6, NCRNA00213
  • Links
    NCBI Gene ID: 100316868

  • Chr Location
    7p15.2; chr7:27198575-27207259 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    2 images
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit limb grasping, decreased grip strength, muscle weakness, decreased gastrocnemius weight with a significant reduction in the number of muscle fibers, and shortened calcanea.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    8
  • cDNA Data
    3
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      27
    • RefSeq
      2
    • UniProt
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 791364 NCBI Gene Model | MGI Sequence Detail 4829 C57BL/6J ±  kb
    transcript NR_110441 RefSeq | MGI Sequence Detail 2879 C57BL/6  
    polypeptide Q8CCA9 UniProt | EBI | MGI Sequence Detail 110 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 4
      Primer pair 3
      Other 1
    References
    more
    • Summaries
      All 15
      Developmental Gene Expression 4
      Gene Ontology 1
      Phenotypes 3
    • Earliest
      J:204277 Sauvageau M, et al., Multiple knockout mouse models reveal lincRNAs are required for life and brain development. Elife. 2013;2(0):e01749
    • Latest
      J:289776 Mao G, et al., Long Non-coding RNA HOTTIP Promotes CCL3 Expression and Induces Cartilage Degradation by Sponging miR-455-3p. Front Cell Dev Biol. 2019;7:161
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/07/2024
    MGI 6.23     		The Jackson Laboratory