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Fer1l5 Gene Detail
Summary
  • Symbol
    Fer1l5
  • Name
    fer-1 like family member 5
  • Synonyms
    4930533C12Rik
Location &
Maps
more
  • Sequence Map
    Chr1:36411372-36461191 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 15.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1539 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3616091
 protein coding gene Chr1:36411264-36461191 (+)
129S1/SvImJ ENSMUSG00200003912
 protein coding gene Chr1:33999720-34049547 (+)
A/J ENSMUSG00195038444
 protein coding gene Chr1:33613621-33663184 (+)
AKR/J ENSMUSG00220008206
 protein coding gene Chr1:33641843-33691468 (+)
BALB/cJ ENSMUSG00180010758
 protein coding gene Chr1:33745046-33794873 (+)
C3H/HeJ ENSMUSG00175001123
 protein coding gene Chr1:33617728-33667297 (+)
C57BL/6NJ ENSMUSG00215025349
 protein coding gene Chr1:33721991-33771831 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014035
 protein coding gene Chr1:31021618-31071032 (+)
CAST/EiJ ENSTCUG00005002685
 protein coding gene Chr1:33791252-33847240 (+)
CBA/J ENSMUSG00210005547
 protein coding gene Chr1:33467186-33516789 (+)
DBA/2J ENSMUSG00185009394
 protein coding gene Chr1:34551517-34601324 (+)
FVB/NJ ENSMUSG00205030103
 protein coding gene Chr1:33646094-33695710 (+)
JF1/MsJ ENSUMUG00000013639
 protein coding gene Chr1:33765079-33815064 (+)
LP/J ENSMUSG00230022741
 protein coding gene Chr1:34620572-34670391 (+)
NOD/ShiLtJ ENSMUSG00190025540
 protein coding gene Chr1:33662143-33711966 (+)
NZO/HlLtJ ENSMUSG00225013422
 protein coding gene Chr1:37855241-37904862 (+)
PWK/PhJ ENSLUMG00010034975
 protein coding gene Chr1:33292467-33342423 (+)
SPRET/EiJ ENSMSPG00010027642
 protein coding gene Chr1:34777847-34827379 (+)
WSB/EiJ ENSIUOG00005034587
 protein coding gene Chr1:33609500-33659204 (+)



Homology
more
  • Human Ortholog
    FER1L5, fer-1 like family member 5
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FER1L5, fer-1 like family member 5
  • Links
    NCBI Gene ID: 90342
    UniProt: A0AVI2

  • Chr Location
    2q11.2; chr2:96642737-96704887 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit severely impaired male fertility due to absent acrosome reaction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037432 Ensembl Gene Model | MGI Sequence Detail 49820 C57BL/6J ±  kb
    transcript ENSMUST00000179162 Ensembl | MGI Sequence Detail 6315 Not Applicable  
    polypeptide ENSMUSP00000142130 Ensembl | MGI Sequence Detail 2038 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 1
    References
    more
    • Summaries
      All 26
      Gene Ontology 6
      Phenotypes 5
    • Earliest
      J:196263 Posey AD Jr, et al., Endocytic recycling proteins EHD1 and EHD2 interact with fer-1-like-5 (Fer1L5) and mediate myoblast fusion. J Biol Chem. 2011 Mar 4;286(9):7379-88
    • Latest
      J:333204 Morohoshi A, et al., Testis-enriched ferlin, FER1L5, is required for Ca(2+)-activated acrosome reaction and male fertility. Sci Adv. 2023 Jan 25;9(4):eade7607
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory