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Lingo3 Gene Detail
Summary
  • Symbol
    Lingo3
  • Name
    leucine rich repeat and Ig domain containing 3
  • Synonyms
    LERN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3609246
    NCBI Gene: 237403
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80668635-80679873 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    246 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3609246
 protein coding gene Chr10:80668635-80679873 (-)
129S1/SvImJ ENSMUSG00200043875
 protein coding gene Chr10:77295287-77306525 (-)
A/J ENSMUSG00195043137
 protein coding gene Chr10:77690507-77701745 (-)
AKR/J ENSMUSG00220047737
 protein coding gene Chr10:77288195-77299433 (-)
BALB/cJ ENSMUSG00180048141
 protein coding gene Chr10:77700974-77712212 (-)
C3H/HeJ ENSMUSG00175047817
 protein coding gene Chr10:77571718-77582956 (-)
C57BL/6NJ ENSMUSG00215048758
 protein coding gene Chr10:77313572-77324810 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015606
 protein coding gene Chr10:74836237-74847427 (-)
CAST/EiJ ENSTCUG00005045723
 protein coding gene Chr10:77200870-77212109 (-)
CBA/J ENSMUSG00210046259
 protein coding gene Chr10:77427760-77438998 (-)
DBA/2J ENSMUSG00185048641
 protein coding gene Chr10:77770212-77781450 (-)
FVB/NJ ENSMUSG00205035673
 protein coding gene Chr10:77482984-77494223 (-)
JF1/MsJ ENSUMUG00000049744
 protein coding gene Chr10:79003797-79015008 (-)
LP/J ENSMUSG00230049434
 protein coding gene Chr10:79539811-79551049 (-)
NOD/ShiLtJ ENSMUSG00190051174
 protein coding gene Chr10:77683911-77695149 (-)
NZO/HlLtJ ENSMUSG00225051685
 protein coding gene Chr10:83826335-83837573 (-)
PWK/PhJ ENSLUMG00010045769
 protein coding gene Chr10:77364403-77375660 (-)
SPRET/EiJ ENSMSPG00010040873
 protein coding gene Chr10:78979410-78990638 (-)
WSB/EiJ ENSIUOG00005048359
 protein coding gene Chr10:77428986-77440221 (-)



Homology
more
  • Human Ortholog
    LINGO3, leucine rich repeat and Ig domain containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LINGO3, leucine rich repeat and Ig domain containing 3
  • Synonyms
    LERN2, LRRN6B
  • Links
    NCBI Gene ID: 645191
    UniProt: P0C6S8

  • Chr Location
    19p13.3; chr19:2287164-2308174 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    643
  • Tissues
    38
  • cDNA Data
    6
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 237403 NCBI Gene Model | MGI Sequence Detail 11239 C57BL/6J ±  kb
    transcript NM_001359746 RefSeq | MGI Sequence Detail 3478 C57BL/6  
    polypeptide Q6GQU6 UniProt | EBI | MGI Sequence Detail 589 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000030939 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3
      (term hierarchy)
    • InterPro Domains
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR003599 Immunoglobulin domain subtype
      IPR013098 Immunoglobulin I-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003598 Immunoglobulin subtype 2
      IPR001611 Leucine-rich repeat
      IPR050541 Leucine-rich repeat and transmembrane domain-containing protein
      IPR032675 Leucine-rich repeat domain superfamily
      IPR000372 Leucine-rich repeat N-terminal domain
      IPR003591 Leucine-rich repeat, typical subtype
    • GlyGen
      Q6GQU6 12 sites, 7 N-linked glycans (7 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 6
      Primer pair 2
      Antibodies 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2143690
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 3
      Gene Ontology 2
      Phenotypes 12
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory