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Slc10a4 Gene Detail
Summary
  • Symbol
    Slc10a4
  • Name
    solute carrier family 10 (sodium/bile acid cotransporter family), member 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:3606480
    NCBI Gene: 231290
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:73164247-73170298 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 38.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3606480
 protein coding gene Chr5:73164226-73170298 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029620
 protein coding gene Chr5:72983621-72992250 (+)
A/J MGP_AJ_G0029588
 protein coding gene Chr5:70247827-70264205 (+)
AKR/J MGP_AKRJ_G0029536
 protein coding gene Chr5:72513153-72519416 (+)
BALB/cJ MGP_BALBcJ_G0029596
 protein coding gene Chr5:70962122-70972623 (+)
C3H/HeJ MGP_C3HHeJ_G0029321
 protein coding gene Chr5:72893400-72898964 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030051
 protein coding gene Chr5:75969977-76001769 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0028722
 protein coding gene Chr5:71520889-71526661 (-)
CBA/J MGP_CBAJ_G0029291
 protein coding gene Chr5:78446954-78454751 (+)
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0029521
 protein coding gene Chr5:73420053-73427500 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029422
 protein coding gene Chr5:81754404-81767701 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030078
 protein coding gene Chr5:71615820-71631716 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0028285
 protein coding gene Chr5:71399436-71430669 (+)
WSB/EiJ MGP_WSBEiJ_G0028803
 protein coding gene Chr5:71884235-71886038 (-)



Homology
more
  • Human Ortholog
    SLC10A4, solute carrier family 10 member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC10A4, solute carrier family 10 member 4
  • Synonyms
    P4
  • Links
    NCBI Gene ID: 201780
    neXtProt AC: NX_Q96EP9
    UniProt: Q96EP9

  • Chr Location
    4p11; chr4:48483343-48489526 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    353 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    3
  • Targeted
    3
  • Genomic Mutations
    6 involving Slc10a4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    13 strains or lines available
Mice homozygous for a null allele exhibit seizures and increased susceptibility to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    34
  • cDNA Data
    12
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 231290 NCBI Gene Model | MGI Sequence Detail 6052 C57BL/6J ±  kb
transcript NM_173403 RefSeq | MGI Sequence Detail 2085 C57BL/6  
polypeptide Q3UEZ8 UniProt | EBI | MGI Sequence Detail 437 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 378
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 6
    Phenotypes 353
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:341974 Harper RL, et al., Mast cell activation and degranulation in acute artery injury: A target for post-operative therapy. FASEB J. 2023 Jul;37(7):e23029
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory