Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Chd7Whi Name: chromodomain helicase DNA binding protein 7; whirligig MGI ID: MGI:3588650 Synonyms: WBE1 Gene: Chd7  Location: Chr4:8690406-8867659 bp, + strand  Genetic Position: Chr4, 3.68 cM Alliance: Chd7Whi page

Malformations of the semicircular canals in Chd7Whi/Chd7+, Tbx1tm1Bld/Tbx1+, and Chd7Whi/Chd7+ Tbx1tm1Bld/Tbx1+ mice Show the 2 phenotype image(s) involving this allele.

Strain of Origin:

C3HeB/FeJ

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: A G2918A transition in exon 11 resulted in a W973X nonsense mutation. This mutation would lead to a protein lacking a large part of the SNF2 and all other more C-terminal located domains. (J:104123) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	9 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	26 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chd7 Mutation:	136 strains or lines available

Original:	J:99481 Hawker K, et al., Two new mouse mutants with vestibular defects that map to the highly mutable locus on chromosome 4. Int J Audiol. 2005 Mar;44(3):171-7
All:	8 reference(s)