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Cntnap3 Gene Detail
Summary
  • Symbol
    Cntnap3
  • Name
    contactin associated protein-like 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3588199
    NCBI Gene: 238680
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:64883996-65051769 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 33.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4304 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3588199
 protein coding gene Chr13:64883994-65051845 (-)
129S1/SvImJ ENSMUSG00200012742
 protein coding gene Chr13:61009597-61171901 (-)
A/J ENSMUSG00195026032
 protein coding gene Chr13:61182376-61337212 (-)
AKR/J ENSMUSG00220032994
 protein coding gene Chr13:60251335-60413648 (-)
BALB/cJ ENSMUSG00180024699
 protein coding gene Chr13:61481908-61636699 (-)
C3H/HeJ ENSMUSG00175007491
 protein coding gene Chr13:61305809-61460691 (-)
C57BL/6NJ ENSMUSG00215011612
 protein coding gene Chr13:61295349-61463127 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018645
 protein coding gene Chr13:60056966-60211578 (-)
CAST/EiJ ENSTCUG00005011573
 protein coding gene Chr13:61644391-61798670 (-)
CBA/J ENSMUSG00210008724
 protein coding gene Chr13:61505278-61660164 (-)
DBA/2J ENSMUSG00185007318
 protein coding gene Chr13:62338012-62492781 (-)
FVB/NJ ENSMUSG00205022423
 protein coding gene Chr13:60475687-60641976 (-)
JF1/MsJ ENSUMUG00000016946
 protein coding gene Chr13:61953872-62121705 (-)
LP/J ENSMUSG00230031768
 protein coding gene Chr13:71686116-71848456 (-)
NOD/ShiLtJ ENSMUSG00190035576
 protein coding gene Chr13:61247362-61402135 (-)
NZO/HlLtJ ENSMUSG00225045454
 protein coding gene Chr13:65398655-65553384 (-)
PWK/PhJ ENSLUMG00010010159
 protein coding gene Chr13:60776373-60936772 (-)
SPRET/EiJ ENSMSPG00010029364
 protein coding gene Chr13:61018008-61211358 (-)
WSB/EiJ ENSIUOG00005023412
 protein coding gene Chr13:59960166-60131447 (-)



Homology
more
  • Human Ortholog
    CNTNAP3, contactin associated protein family member 3
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNTNAP3, contactin associated protein family member 3
  • Synonyms
    CASPR3, CNTNAP3A
  • Links
    NCBI Gene ID: 79937
    UniProt: Q9BZ76

  • Chr Location
    9p12; chr9:39064710-39288611 (-)  GRCh38
  • Human Ortholog
    CNTNAP3B, contactin associated protein family member 3B
  • Links
    NCBI Gene ID: 728577
    UniProt: Q96NU0

  • Chr Location
    9p11.2; chr9:41890314-42129552 (-)  GRCh38
  • Human Ortholog
    CNTNAP3C, contactin associated protein family member 3C
  • Links
    NCBI Gene ID: 100289279

  • Chr Location
    chr9:61330441-61461466 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal brain morphology but impaired motor learning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    612
  • Tissues
    3
  • cDNA Data
    5
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033063 Ensembl Gene Model | MGI Sequence Detail 167774 C57BL/6J ±  kb
transcript ENSMUST00000091554 Ensembl | MGI Sequence Detail 6344 Not Applicable  
polypeptide ENSMUSP00000089140 Ensembl | MGI Sequence Detail 1287 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR000421 Coagulation factor 5/8, C-terminal domain
    IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    IPR000742 EGF-like domain
    IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
    IPR036056 Fibrinogen-like, C-terminal
    IPR008979 Galactose-binding-like domain superfamily
    IPR001791 Laminin G domain
    IPR050372 Neurexin-related cell adhesion and synaptic protein
  • GlyGen
    E9PY62 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 6
References
more
  • Summaries
    All 33
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory