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Lrp3 Gene Detail
Summary
  • Symbol
    Lrp3
  • Name
    low density lipoprotein receptor-related protein 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3584516
    NCBI Gene: 435965
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:34900303-34914770 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 21.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    378 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3584516
 protein coding gene Chr7:34899452-34914923 (-)
129S1/SvImJ ENSMUSG00200022628
 protein coding gene Chr7:23646439-23662746 (-)
A/J ENSMUSG00195038611
 protein coding gene Chr7:26611602-26627935 (-)
AKR/J ENSMUSG00220024427
 protein coding gene Chr7:14433454-14449754 (-)
BALB/cJ ENSMUSG00180016468
 protein coding gene Chr7:24167684-24184007 (-)
C3H/HeJ ENSMUSG00175027070
 protein coding gene Chr7:24693384-24709682 (-)
C57BL/6NJ ENSMUSG00215008784
 protein coding gene Chr7:24052816-24069113 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029581
 protein coding gene Chr7:34371629-34386782 (-)
CAST/EiJ ENSTCUG00005039510
 protein coding gene Chr7:25809214-25825704 (-)
CBA/J ENSMUSG00210024895
 protein coding gene Chr7:24712204-24728498 (-)
DBA/2J ENSMUSG00185048051
 protein coding gene Chr7:27463566-27479896 (-)
FVB/NJ ENSMUSG00205010469
 protein coding gene Chr7:24453995-24470316 (-)
JF1/MsJ ENSUMUG00000030005
 protein coding gene Chr7:31941498-31958079 (-)
LP/J ENSMUSG00230011550
 protein coding gene Chr7:33145859-33162173 (-)
NOD/ShiLtJ ENSMUSG00190008236
 protein coding gene Chr7:24312195-24328509 (-)
NZO/HlLtJ ENSMUSG00225008288
 protein coding gene Chr7:31505931-31522487 (-)
PWK/PhJ ENSLUMG00010019987
 protein coding gene Chr7:23877616-23894150 (-)
SPRET/EiJ ENSMSPG00010004952
 protein coding gene Chr7:23919348-23933421 (-)
WSB/EiJ ENSIUOG00005007648
 protein coding gene Chr7:24489645-24505948 (-)



Homology
more
  • Human Ortholog
    LRP3, LDL receptor related protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRP3, LDL receptor related protein 3
  • Links
    NCBI Gene ID: 4037
    UniProt: O75074

  • Chr Location
    19q13.11; chr19:33177603-33208864 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit accelerated post-injury osteoarthritis and senescence-induced osteoarthritis development. Mice show reduced weight gain and increased total cholesterol serum levels on a high cholesterol diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 435965 NCBI Gene Model | MGI Sequence Detail 14468 C57BL/6J ±  kb
    transcript NM_001024707 RefSeq | MGI Sequence Detail 4007 C57BL/6  
    polypeptide NP_001019878 RefSeq | MGI Sequence Detail 790 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR000859 CUB domain
      IPR036055 LDL receptor-like superfamily
      IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR050685 Low-density lipoprotein receptor
      IPR035914 Spermadhesin, CUB domain superfamily
    • GlyGen
      E9Q711 1 site, 2 N-linked glycans (1 site)
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 1
    References
    more
    • Summaries
      All 26
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:345338 Cao C, et al., Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4. Nat Commun. 2022 Nov 21;13(1):7139
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory