Agap2 MGI Mouse Gene Detail - MGI:3580016 - ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

Symbol

Agap2
Name

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Synonyms

Centg1, PIKE-A, PIKE-L

Feature Type

protein coding gene
IDs

MGI:3580016
NCBI Gene: 216439
Alliance

genome feature page
Transcription Start Sites

17 TSS

Sequence Map

Chr10:126911154-126929039 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 74.50 cM
Mapping Data

1 experiment

SNPs within 2kb

385 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3580016	protein coding gene	Chr10:126911153-126929039 (+)
129S1/SvImJ	ENSMUSG00200011771	protein coding gene	Chr10:123263901-123281807 (+)
A/J	ENSMUSG00195015083	protein coding gene	Chr10:123728208-123746095 (+)
AKR/J	ENSMUSG00220005631	protein coding gene	Chr10:123332510-123350415 (+)
BALB/cJ	ENSMUSG00180009578	protein coding gene	Chr10:123719292-123737184 (+)
C3H/HeJ	ENSMUSG00175005785	protein coding gene	Chr10:123717065-123734966 (+)
C57BL/6NJ	ENSMUSG00215007919	protein coding gene	Chr10:123329322-123347204 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015880	protein coding gene	Chr10:119447892-119462068 (+)
CAST/EiJ	ENSTCUG00005041279	protein coding gene	Chr10:122686679-122704294 (+)
CBA/J	ENSMUSG00210007939	protein coding gene	Chr10:123541236-123559143 (+)
DBA/2J	ENSMUSG00185026767	protein coding gene	Chr10:123687634-123705493 (+)
FVB/NJ	ENSMUSG00205016708	protein coding gene	Chr10:122946975-122964866 (+)
JF1/MsJ	ENSUMUG00000043061	protein coding gene	Chr10:124983129-125000806 (+)
LP/J	ENSMUSG00230031656	protein coding gene	Chr10:125604684-125622533 (+)
NOD/ShiLtJ	ENSMUSG00190015615	protein coding gene	Chr10:123769475-123787364 (+)
NZO/HlLtJ	ENSMUSG00225037455	protein coding gene	Chr10:129811810-129829716 (+)
PWK/PhJ	ENSLUMG00010008489	protein coding gene	Chr10:123442268-123459933 (+)
SPRET/EiJ	ENSMSPG00010031896	protein coding gene	Chr10:125396542-125414106 (+)
WSB/EiJ	ENSIUOG00005007082	protein coding gene	Chr10:123328210-123346113 (+)

Human Ortholog

AGAP2, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AGAP2, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Synonyms

CENTG1, GGAP2, PIKE
Links

HGNC:16921

NCBI Gene ID: 116986

UniProt: Q99490
Chr Location

12q14.1; chr12:57723761-57742161 (-) GRCh38

MGI Vertebrate Homology

Agap2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AGAP2
Gene Tree

Agap2

Diseases

1 with human AGAP2 associations

				Human Disease	Mouse Models
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

18 phenotypes from 2 alleles in 3 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired lactation due to abnormal mammary gland growth during lactation, failure of insulin-suppressed gluconeogenesis, and hyperglycemia.

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All GO Annotations

69
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

8
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase agap2

ZFIN agap2

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All Sequences

48
RefSeq

14
UniProt

2
CCDS

CCDS24228.1, CCDS88097.1

Ensembl

ENSMUSG00000025422 (Evidence)
NCBI Gene

216439

			Length	Strain/Species	Flank
genomic	216439	NCBI Gene Model \| MGI Sequence Detail	17886	C57BL/6J	± kb
transcript	NM_001033263	RefSeq \| MGI Sequence Detail	5645	C57BL/6
polypeptide	Q3UHD9	UniProt \| EBI \| MGI Sequence Detail	1186	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003816 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR038508 ArfGAP domain superfamily

IPR037278 ARFGAP/RecO-like, zinc finger superfamily

IPR001164 Arf GTPase activating protein

IPR051282 Centaurin-gamma/AGAP

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase
GlyGen

Q3UHD9 7 sites, 1 O-linked glycan (6 sites)

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All nucleic 8

cDNA 8

Microarray probesets 3

Summaries

All 47

Developmental Gene Expression 1

Gene Ontology 11

Phenotypes 15
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:380744 Wehle DT, et al., Dissociation of the mTOR Protein Interaction Network Following Neuronal Activation Is Altered by Shank3 Mutation. J Neurochem. 2026 Jan;170(1):e70353

TSS for Agap2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96119	Chr10:126911134-126911194 (+)	10 bp
Tssr96120	Chr10:126911198-126911267 (+)	79 bp
Tssr96121	Chr10:126914755-126914787 (+)	3,617 bp
Tssr96122	Chr10:126914791-126914815 (+)	3,649 bp
Tssr96123	Chr10:126914833-126914834 (+)	3,680 bp
Tssr96124	Chr10:126914857-126914860 (+)	3,705 bp
Tssr96125	Chr10:126914875-126914893 (+)	3,730 bp
Tssr96126	Chr10:126914903-126914904 (+)	3,750 bp
Tssr96127	Chr10:126914909-126914938 (+)	3,770 bp
Tssr96128	Chr10:126914984-126914996 (+)	3,836 bp
Tssr96129	Chr10:126915028-126915039 (+)	3,880 bp
Tssr96130	Chr10:126920450-126920455 (+)	9,299 bp
Tssr96131	Chr10:126920525-126920542 (+)	9,380 bp
Tssr96132	Chr10:126920595-126920615 (+)	9,451 bp
Tssr96133	Chr10:126922765-126922775 (+)	11,616 bp
Tssr96134	Chr10:126928536-126928557 (+)	17,393 bp
Tssr96135	Chr10:126928906-126928910 (+)	17,754 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24