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Serpinb3a Gene Detail
Summary
  • Symbol
    Serpinb3a
  • Name
    serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
  • Synonyms
    Scca2, Serpinb4, Sqn5
  • Feature Type
    protein coding gene
  • IDs
    MGI:3573933
    NCBI Gene: 20248
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:106973317-106980033 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 50.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    371 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3573933
 protein coding gene Chr1:106973317-106980033 (-)
129S1/SvImJ ENSMUSG00200000324
 protein coding gene Chr1:104278249-104284969 (-)
A/J ENSMUSG00195007740
 protein coding gene Chr1:103758316-103765012 (-)
AKR/J ENSMUSG00220000195
 protein coding gene Chr1:103850260-103856956 (-)
BALB/cJ ENSMUSG00180000332
 protein coding gene Chr1:104044131-104050825 (-)
C3H/HeJ ENSMUSG00175000543
 protein coding gene Chr1:103973382-103980078 (-)
C57BL/6NJ ENSMUSG00215005935
 protein coding gene Chr1:103968362-103975076 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014495
 protein coding gene Chr1:99744826-99750620 (-)
CAST/EiJ ENSTCUG00005002766
 protein coding gene Chr1:103297262-103303969 (-)
CBA/J ENSMUSG00210000093
 protein coding gene Chr1:103853501-103860197 (-)
DBA/2J ENSMUSG00185008148
 protein coding gene Chr1:108301506-108308230 (-)
FVB/NJ no annotation
JF1/MsJ ENSUMUG00000000108
 protein coding gene Chr1:106878715-106885447 (-)
LP/J ENSMUSG00230000071
 protein coding gene Chr1:107564226-107570948 (-)
NOD/ShiLtJ ENSMUSG00190000263
 protein coding gene Chr1:103911937-103918656 (-)
NZO/HlLtJ ENSMUSG00225000266
 protein coding gene Chr1:111453031-111459726 (-)
PWK/PhJ ENSLUMG00010000130
 protein coding gene Chr1:103279623-103286350 (-)
SPRET/EiJ ENSMSPG00010000504
 protein coding gene Chr1:105574950-105581684 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SERPINB3, serpin family B member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINB3, serpin family B member 3
  • Synonyms
    HsT1196, SCC, SCCA-1, SCCA1, SCCA-PD, SSCA1, T4-A
  • Links
    NCBI Gene ID: 6317
    UniProt: P29508

  • Chr Location
    18q21.33; chr18:63653686-63661893 (-)  GRCh38
  • Human Ortholog
    SERPINB4, serpin family B member 4
  • Synonyms
    LEUPIN, PI11, SCCA1, SCCA-2, SCCA2
  • Links
    NCBI Gene ID: 6318
    UniProt: P48594

  • Chr Location
    18q21.33; chr18:63637259-63644256 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced susceptibility to allergen-induced airway hyperresponsiveness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    5
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20248 NCBI Gene Model | MGI Sequence Detail 6717 C57BL/6J ±  kb
transcript NM_009126 RefSeq | MGI Sequence Detail 1629 C57BL/6  
polypeptide NP_033152 RefSeq | MGI Sequence Detail 387 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    Genomic 1
    cDNA 5

    Microarray probesets 7
References
more
  • Summaries
    All 40
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:335153 Qiu T, et al., Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling. Development. 2023 Apr 1;150(7):dev201464
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory