About   Help   FAQ
Rnase12 Gene Detail
Summary
  • Symbol
    Rnase12
  • Name
    ribonuclease, RNase A family, 12 (non-active)
  • Feature Type
    protein coding gene
  • IDs
    MGI:3528588
    NCBI Gene: 497106
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:51294155-51294699 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.36 cM, cytoband B-C1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    115 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3528588
 protein coding gene Chr14:51294155-51295118 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021269
 protein coding gene Chr14:45006172-45006716 (-)
A/J MGP_AJ_G0021223
 protein coding gene Chr14:43658198-43658742 (-)
AKR/J MGP_AKRJ_G0021199
 protein coding gene Chr14:45306946-45307490 (-)
BALB/cJ MGP_BALBcJ_G0021226
 protein coding gene Chr14:43782086-43782630 (-)
C3H/HeJ MGP_C3HHeJ_G0021008
 protein coding gene Chr14:45131160-45131704 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021663
 protein coding gene Chr14:46869149-46869693 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019215
 protein coding gene Chr14:42993386-42993930 (-)
CAST/EiJ MGP_CASTEiJ_G0020532
 protein coding gene Chr14:42204553-42205097 (-)
CBA/J MGP_CBAJ_G0020975
 protein coding gene Chr14:48321442-48321986 (-)
DBA/2J MGP_DBA2J_G0021099
 protein coding gene Chr14:43552516-43553060 (-)
FVB/NJ MGP_FVBNJ_G0021080
 protein coding gene Chr14:43179387-43179931 (-)
LP/J MGP_LPJ_G0021167
 protein coding gene Chr14:45297776-45298320 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021108
 protein coding gene Chr14:47813613-47814157 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021692
 protein coding gene Chr14:44789096-44789640 (-)
PWK/PhJ MGP_PWKPhJ_G0020282
 protein coding gene Chr14:40456053-40456597 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020107
 protein coding gene Chr14:40963577-40964121 (-)
WSB/EiJ MGP_WSBEiJ_G0020585
 protein coding gene Chr14:44993362-44993906 (-)



Homology
more
  • Human Ortholog
    RNASE12, ribonuclease A family member 12 (inactive)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNASE12, ribonuclease A family member 12 (inactive)
  • Synonyms
    HEL-S-85p, RAI1
  • Links
    NCBI Gene ID: 493901
    UniProt: Q5GAN4

  • Chr Location
    14q11.2; chr14:20590073-20591376 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 497106 NCBI Gene Model | MGI Sequence Detail 545 C57BL/6J ±  kb
    transcript NM_001011875 RefSeq | MGI Sequence Detail 545 Not Specified  
    polypeptide Q5GAM8 UniProt | EBI | MGI Sequence Detail 145 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 1
    References
    more
    • Summaries
      All 23
      Gene Ontology 1
      Phenotypes 9
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:364178 Shaffer JF, et al., Epididymis-specific RNase A family genes regulate fertility and small RNA processing. J Biol Chem. 2024 Oct 28;300(12):107933
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory