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Trpa1 Gene Detail
Summary
  • Symbol
    Trpa1
  • Name
    transient receptor potential cation channel, subfamily A, member 1
  • Synonyms
    ANKTM1
Location &
Maps
more
  • Sequence Map
    Chr1:14942872-14989086 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 4.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1891 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3522699
 protein coding gene Chr1:14942868-14989086 (-)
129S1/SvImJ ENSMUSG00200018453
 protein coding gene Chr1:12331305-12378299 (-)
A/J ENSMUSG00195026629
 protein coding gene Chr1:12109084-12155315 (-)
AKR/J ENSMUSG00220007916
 protein coding gene Chr1:12189423-12235659 (-)
BALB/cJ ENSMUSG00180022784
 protein coding gene Chr1:12175428-12221660 (-)
C3H/HeJ ENSMUSG00175000195
 protein coding gene Chr1:12108397-12154629 (-)
C57BL/6NJ ENSMUSG00215009624
 protein coding gene Chr1:12145565-12191798 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013960
 protein coding gene Chr1:10770785-10817337 (-)
CAST/EiJ ENSTCUG00005021691
 protein coding gene Chr1:12492269-12539329 (-)
CBA/J ENSMUSG00210002577
 protein coding gene Chr1:11974470-12020708 (-)
DBA/2J ENSMUSG00185003705
 protein coding gene Chr1:13048180-13095166 (-)
FVB/NJ ENSMUSG00205012560
 protein coding gene Chr1:12252419-12298652 (-)
JF1/MsJ ENSUMUG00000014919
 protein coding gene Chr1:12324758-12374264 (-)
LP/J ENSMUSG00230015875
 protein coding gene Chr1:13032679-13079676 (-)
NOD/ShiLtJ ENSMUSG00190028919
 protein coding gene Chr1:12082411-12128641 (-)
NZO/HlLtJ ENSMUSG00225005102
 protein coding gene Chr1:16409140-16455369 (-)
PWK/PhJ ENSLUMG00010021181
 protein coding gene Chr1:11938997-11987038 (-)
SPRET/EiJ ENSMSPG00010025294
 protein coding gene Chr1:12709098-12756368 (-)
WSB/EiJ ENSIUOG00005011436
 protein coding gene Chr1:12100733-12146953 (-)



Homology
more
  • Human Ortholog
    TRPA1, transient receptor potential cation channel subfamily A member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPA1, transient receptor potential cation channel subfamily A member 1
  • Synonyms
    ANKTM1, FEPS, FEPS1, p120
  • Links
    NCBI Gene ID: 8989
    UniProt: O75762

  • Chr Location
    8q21.11; chr8:72019608-72090010 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TRPA1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 8 alleles in 7 genetic backgrounds
    266 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in altered nociception and neuron responses to isothiocyanate or thiosulfinate compounds like those found in mustard oil and garlic.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    103
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    681
  • Tissues
    58
  • cDNA Data
    8
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032769 Ensembl Gene Model | MGI Sequence Detail 46215 C57BL/6J ±  kb
    transcript ENSMUST00000041447 Ensembl | MGI Sequence Detail 4263 Not Applicable  
    polypeptide ENSMUSP00000043594 Ensembl | MGI Sequence Detail 1125 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 8
      Primer pair 3
      Other 3
      Antibodies 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 385
      Developmental Gene Expression 20
      Gene Ontology 23
      Phenotypes 266
    • Earliest
      J:96171 Story GM, et al., ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003 Mar 21;112(6):819-29
    • Latest
      J:389898 Drew VJ, et al., A TREK-1/AQP4/TRPA1/BDNF Signaling Axis Is Associated With Astrocytic Volume Transients, Synaptic Plasticity, and Spatial Memory. Glia. 2026 Sep;74(9):e70195
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory