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Nlrp4b Gene Detail
Summary
  • Symbol
    Nlrp4b
  • Name
    NLR family, pyrin domain containing 4B
  • Synonyms
    Nalp4b, NALP9E, Nalp-gamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:3056570
    NCBI Gene: 210045
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:10421720-10464095 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 6.58 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1327 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3056570
 protein coding gene Chr7:10421716-10464095 (+)
129S1/SvImJ ENSMUSG00200037211
 protein coding gene Chr7:4795764-4815855 (+)
A/J ENSMUSG00195045717
 protein coding gene Chr7:4659693-4679774 (+)
AKR/J ENSMUSG00220026529
 protein coding gene Chr7:4370337-4390410 (+)
BALB/cJ ENSMUSG00180046253
 protein coding gene Chr7:4536314-4556391 (+)
C3H/HeJ ENSMUSG00175045791
 protein coding gene Chr7:4683588-4703674 (+)
C57BL/6NJ ENSMUSG00215035057
 protein coding gene Chr7:5147427-5167512 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005026879
 protein coding gene Chr7:4872860-4899286 (+)
CBA/J ENSMUSG00210045319
 protein coding gene Chr7:4470012-4490098 (+)
DBA/2J ENSMUSG00185034873
 protein coding gene Chr7:7317338-7337422 (+)
FVB/NJ ENSMUSG00205043375
 protein coding gene Chr7:4962563-4982653 (+)
JF1/MsJ ENSUMUG00000022233
 protein coding gene Chr7:7324385-7350750 (+)
LP/J ENSMUSG00230040662
 protein coding gene Chr7:11499704-11519792 (+)
NOD/ShiLtJ ENSMUSG00190032244
 protein coding gene Chr7:4737080-4757161 (+)
NZO/HlLtJ ENSMUSG00225017490
 protein coding gene Chr7:9362065-9382147 (+)
PWK/PhJ ENSLUMG00010036617
 protein coding gene Chr7:8585455-8604120 (+)
SPRET/EiJ ENSMSPG00010041413
 protein coding gene Chr7:4834479-4854549 (+)
WSB/EiJ ENSIUOG00005049683
 protein coding gene Chr7:4863761-4883855 (+)



Homology
more
  • Human Ortholog
    NLRP4, NLR family pyrin domain containing 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRP4, NLR family pyrin domain containing 4
  • Synonyms
    CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2
  • Links
    NCBI Gene ID: 147945
    UniProt: Q96MN2

  • Chr Location
    19q13.43; chr19:55836540-55881855 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    614
  • Tissues
    12
  • cDNA Data
    23
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 210045 NCBI Gene Model | MGI Sequence Detail 42376 C57BL/6J ±  kb
transcript NM_001355151 RefSeq | MGI Sequence Detail 3323 C57BL/6  
polypeptide Q8C6J9 UniProt | EBI | MGI Sequence Detail 863 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000011564 NACHT, LRR and PYD domains-containing protein 4B
    (term hierarchy)
  • InterPro Domains
    IPR004020 DAPIN domain
    IPR011029 Death-like domain superfamily
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2
    IPR007111 NACHT nucleoside triphosphatase
    IPR050637 NLRP family, innate immunity and inflammation regulators
    IPR041075 NOD1/2, winged helix domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 24
    cDNA 23
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142143
References
more
  • Summaries
    All 26
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 1
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory