Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Polid
Name:	polymerase (DNA directed), iota; polymerase iota deficient
MGI ID:	MGI:3055735
Synonyms:	Poli-, Poli129
Gene:	Poli  Location: Chr18:70641751-70663691 bp, - strand  Genetic Position: Chr18, 44.48 cM, cytoband E2
Alliance:	Polid page

Strain of Origin:

129

Allele Type:    Spontaneous (Null/knockout) Mutation:    Single point mutation   Mutation details: A C-to-A nonsense mutation changes codon 27 from serine (TCG) to an amber stop codon (TAG) (SW:Q6R3M4 p.S27*), and results in a truncated protein lacking any catalytic function. The allele was present in every 129 strain analyzed, including 129P3/J, 129X1/SvJ, 129P1/ReJ and 129P2/Ola. C57BL/6J and BALB/c mice did not contain the mutation. (J:85061, J:228234, J:273998) Inheritance:    Not Specified

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Poli Mutation:	45 strains or lines available

Original:	J:85061 McDonald JP, et al., 129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation. J Exp Med. 2003 Aug 18;198(4):635-43
All:	10 reference(s)