Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Plscr3tm1Sims
Name:	phospholipid scramblase 3; targeted mutation 1, Peter J Sims
MGI ID:	MGI:3053448
Synonyms:	PLSCR3-, Plscr3Gt(Betageo)1Sims
Gene:	Plscr3  Location: Chr11:69737202-69742884 bp, + strand  Genetic Position: Chr11, 42.9 cM
Alliance:	Plscr3tm1Sims page

Germline Transmission:	Earliest citation of germline transmission: J:92404
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEvBrd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A gene trap vector containing pKOS-lacZ/MC1neo (Lexicon Genetics, Woodlands, TX) was inserted to replace the first four exons of the gene. Western blot analysis on platelets, lung, muscle and adipocytes did not detect protein. (J:92404)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plscr3 Mutation:	20 strains or lines available

Original:	J:92404 Wiedmer T, et al., Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3). Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13296-301
All:	2 reference(s)