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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Plscr3tm1Sims
targeted mutation 1, Peter J Sims
MGI:3053448
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Plscr3tm1Sims/Plscr3tm1Sims involves: 129S/SvEvBrd * C57BL/6J MGI:3053798
cx2
Plscr1tm1Lex/Plscr1tm1Lex
Plscr3tm1Sims/Plscr3tm1Sims
involves: 129S7/SvEvBrd * C57BL/6J MGI:3053804


Genotype
MGI:3053798
hm1
Allelic
Composition
Plscr3tm1Sims/Plscr3tm1Sims
Genetic
Background
involves: 129S/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plscr3tm1Sims mutation (0 available); any Plscr3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• increased size of adipocytes
• aberrant accumulation of abdominal fat by 2 months of age

growth/size/body
• body weight elevated by 2 months
• mild obesity at 19 weeks

homeostasis/metabolism
• elevation in plasma leptin at 19 weeks
• mild hyperglycemia by 2 months of age, persisting to at least 6 months
• glucose intolerance by two months of age
• insulin resistance by two months of age
• adipocytes exhibit defective response to exogenous insulin
• low levels of plasma adiponectin, ~50% decrease at 8 and 19 weeks
• dyslipidemia
• increase in size and number of lipid droplets in bone marrow derived granulocytes and macrophages
• greater than 2 fold increase in cholesterol associated with VLDL and LDL at 19 weeks, smaller increase in HDL
• elevated plasma nonesterified fatty acid levels by 19 weeks

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
obesity DOID:9970 OMIM:601665
J:92404




Genotype
MGI:3053804
cx2
Allelic
Composition
Plscr1tm1Lex/Plscr1tm1Lex
Plscr3tm1Sims/Plscr3tm1Sims
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plscr1tm1Lex mutation (2 available); any Plscr1 mutation (27 available)
Plscr3tm1Sims mutation (0 available); any Plscr3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• bone marrow cells exhibit impaired maturation in response to growth factors

homeostasis/metabolism
• glucose intolerance by two months of age
• increase in size and number of lipid droplets in bone marrow derived granulocytes and macrophages

immune system
• bone marrow cells exhibit impaired maturation in response to growth factors





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory