Summary | Transgene origin | Transgene description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Apoa2)1Lus
Name:	transgene insertion 1, Aldons J Lusis
MGI ID:	MGI:3052796
Transgene:	Tg(Apoa2)1Lus  Location: unknown
Alliance:	Tg(Apoa2)1Lus page

Strain of Origin:

(C57BL/6J x DBA/2J)F1 x C57BL/6J

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Apoa2)1Lus expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Apoa2 (MGI:88050)   Mutation details: The transgene contains mouse apolipoprotein A-II sequence from Swiss 3T3 cells with 4.5 kb of upstream sequence and 8.5 kb of downstream sequence. About 10 copies of the transgene integrated into the genome. The apoA-II expressed from the Swiss 3T3 cell genomic clone carries a more basic apoA-II allele (found among many inbred strains of mice) than the C57BL/6J apoA-II allele. Expression of the transgene in the liver was 4-fold higher than endogenous gene expression. (J:92454)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:92454 Hedrick CC, et al., Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice. J Biol Chem. 1993 Sep 25;268(27):20676-82
All:	8 reference(s)