Phenotypes associated with this allele

• Allele Symbol: Tg(Apoa2)1Lus
• Allele Name: transgene insertion 1, Aldons J Lusis
• Allele ID: MGI:3052796
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Apoa2)1Lus/?	involves: C57BL/6J * DBA/2	MGI:3800790

Genotype
MGI:3800790

tg1

• Allelic Composition: Tg(Apoa2)1Lus/?
• Genetic Background: involves: C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:92454 , J:127063 )

• fasting plasma levels of apolioprotein-2 (apoA-II) are 3 fold higher than in non-transgenic controls (J:92454)

• fasting levels of apoA-II are 1.5 higher in male transgenic mice than in female transgenic mice (J:92454)

• the ratio of plasma levels of apoA-II to apoA-I averages 2- to 3- fold higher than in non-transgenic controls (J:92454)

• size of HDL and LDL complexes in the blood are larger than in controls and are enriched for apoA-II protein (J:92454)

• apo-E protein is found only in LDL complexes and not HDL complexes (J:92454)

• plasma levels of apolioprotein-2 (apoA-II) are 2- to 3-fold higher on a chow diet than in non-transgenic controls (J:127063)

• levels of apoA-II are 1.5 higher on a chow diet in male transgenic mice than in female transgenic mice (J:127063)

• the ratio of plasma levels of apoA-II to apoA-I averages 2- to 3- fold higher on a chow diet than in non-transgenic controls (J:127063)

• size of HDL complexes in the blood are larger than in controls (J:127063)

• a complex rich in cholesteryl-ester containing Apo-AII and Apo-E and having a size in between LDL and HDL complexes is found in the sera of transgenic mice (J:127063)

• the amounts of this intermediate-sized complex increases with an atherogenic diet (J:127063)

increased circulating cholesterol level ( J:92454 , J:127063 )

• total circulating cholesterol levels are elevated more than 2-fold (J:92454)

• total circulating cholesterol levels are elevated more than 2-fold on a chow diet (J:127063)

• cholesterol levels remain elevated compared to control mice when both are fed an artherogenic diet (J:127063)

increased circulating HDL cholesterol level ( J:92454 , J:127063 )

• level of HDL- cholesterol are 2-fold higher for both males and females compared to non-transgenic controls (J:92454)

• level of HDL- cholesterol are 2-fold higher on a chow diet for both males and females compared to non-transgenic controls (J:127063)

• cholesterol levels remain elevated compared to control mice when both are fed an artherogenic diet (J:127063)

increased circulating LDL cholesterol level ( J:92454 )

• VLDL/LDL cholesterol levels are 113 and 78 mg/dl for male and female mice respectively, compared to 33 mg/dl for both sexes in non-transgenic mice

increased circulating VLDL cholesterol level ( J:92454 )

• VLDL/LDL cholesterol levels are 113 and 78 mg/dl for male and female mice respectively, compared to 33 mg/dl for both sexes in non-transgenic mice

increased circulating triglyceride level ( J:92454 )

• total plasma triglyceride levels are 2- to 3-fold higher than in non-transgenic mice

cardiovascular system

atherosclerotic lesions ( J:127063 )

• mice develop atherosclerotic lesions with a mean size of 2020 micrometers² by 4- to 6-months of age

• lesions consist of fatty streaks with subendothelial accumulations of lipid and foam cells

• lesions resemble those that occur in C57BL/6J mice fed a high fat, high cholesterol diet

• male but not female mice maintained on a atherogenic diet for 11 to 12 weeks have an increased lesion size compared to sex-matched non-transgenic controls