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Fbxw10 Gene Detail
Summary
  • Symbol
    Fbxw10
  • Name
    F-box and WD-40 domain protein 10
  • Synonyms
    Fbw10, SM25H2, SM2SH2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3052463
    NCBI Gene: 213980
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:62737895-62768291 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 38.78 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    268 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3052463
 protein coding gene Chr11:62737893-62768291 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018464
 protein coding gene Chr11:62936355-62971827 (+)
A/J MGP_AJ_G0018433
 protein coding gene Chr11:60593267-60627697 (+)
AKR/J MGP_AKRJ_G0018402
 protein coding gene Chr11:62460691-62494280 (+)
BALB/cJ MGP_BALBcJ_G0018404
 protein coding gene Chr11:60871527-60902383 (+)
C3H/HeJ MGP_C3HHeJ_G0018217
 protein coding gene Chr11:62435978-62467134 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018856
 protein coding gene Chr11:64901883-64936326 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016500
 protein coding gene Chr11:57673345-57703781 (+)
CAST/EiJ MGP_CASTEiJ_G0017773
 protein coding gene Chr11:62593822-62627596 (+)
CBA/J MGP_CBAJ_G0018191
 protein coding gene Chr11:67696963-67736457 (+)
DBA/2J MGP_DBA2J_G0018300
 protein coding gene Chr11:60145019-60176739 (+)
FVB/NJ MGP_FVBNJ_G0018290
 protein coding gene Chr11:59813365-59843729 (+)
LP/J MGP_LPJ_G0018372
 protein coding gene Chr11:63464636-63498695 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018314
 protein coding gene Chr11:68684228-68717080 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018897
 protein coding gene Chr11:62619346-62650475 (+)
PWK/PhJ MGP_PWKPhJ_G0017547
 protein coding gene Chr11:60765011-60796803 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017337
 protein coding gene Chr11:62468663-62504067 (+)
WSB/EiJ MGP_WSBEiJ_G0017826
 protein coding gene Chr11:62236011-62269487 (+)



Homology
more
  • Human Ortholog
    FBXW10, F-box and WD repeat domain containing 10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXW10, F-box and WD repeat domain containing 10
  • Synonyms
    Fbw10, HREP, SM25H2, SM2SH2
  • Links
    NCBI Gene ID: 10517
    neXtProt AC: NX_Q5XX13
    UniProt: Q5XX13

  • Chr Location
    17p11.2; chr17:18744026-18779349 (+)  GRCh38
  • Human Ortholog
    FBXW10B, F-box and WD repeat domain containing 10B
  • Synonyms
    C170RF1, C17ORF1, C17ORF1A, CDRT1, FBXW10P1, HREP, SM25H2
  • Links
    NCBI Gene ID: 374286
    neXtProt AC: NX_O95170
    UniProt: O95170

  • Chr Location
    17p12; chr17:15565482-15619704 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000090173 Ensembl Gene Model | MGI Sequence Detail 30397 C57BL/6J ±  kb
    transcript ENSMUST00000036085 Ensembl | MGI Sequence Detail 3354 Not Applicable  
    polypeptide ENSMUSP00000046156 Ensembl | MGI Sequence Detail 1030 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR001810 F-box domain
      IPR036047 F-box-like domain superfamily
      IPR020472 G-protein beta WD-40 repeat
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 14

      Microarray probesets 2
    References
    more
    • Summaries
      All 28
      Phenotypes 8
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:338534 Lin XT, et al., Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice. Cell Rep. 2023 Jul 25;42(7):112812
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory