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Pusl1 Gene Detail
Summary
  • Symbol
    Pusl1
  • Name
    pseudouridylate synthase-like 1
  • Synonyms
    2810021I11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3047787
    NCBI Gene: 433813
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:155973314-155976231 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 87.66 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3047787
 protein coding gene Chr4:155972336-155976238 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029237
 protein coding gene Chr4:160260456-160264562 (-)
A/J MGP_AJ_G0029202
 protein coding gene Chr4:153506884-153510990 (-)
AKR/J MGP_AKRJ_G0029150
 protein coding gene Chr4:157684895-157689001 (-)
BALB/cJ MGP_BALBcJ_G0029218
 protein coding gene Chr4:153980005-153984111 (-)
C3H/HeJ MGP_C3HHeJ_G0028939
 protein coding gene Chr4:158227609-158231715 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029667
 protein coding gene Chr4:165938199-165942101 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026911
 protein coding gene Chr4:145794159-145798049 (-)
CAST/EiJ MGP_CASTEiJ_G0028351
 protein coding gene Chr4:155698672-155702566 (-)
CBA/J MGP_CBAJ_G0028901
 protein coding gene Chr4:170954638-170958744 (-)
DBA/2J MGP_DBA2J_G0029050
 protein coding gene Chr4:153527616-153532183 (-)
FVB/NJ MGP_FVBNJ_G0029013
 protein coding gene Chr4:152778913-152782809 (-)
LP/J MGP_LPJ_G0029140
 protein coding gene Chr4:160190232-160194338 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029040
 protein coding gene Chr4:173764273-173768169 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029699
 protein coding gene Chr4:158313519-158321637 (-)
PWK/PhJ MGP_PWKPhJ_G0028072
 protein coding gene Chr4:149671240-149675142 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027906
 protein coding gene Chr4:152573567-152577486 (-)
WSB/EiJ MGP_WSBEiJ_G0028431
 protein coding gene Chr4:158487786-158491892 (-)



Homology
more
  • Human Ortholog
    PUSL1, pseudouridine synthase like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PUSL1, pseudouridine synthase like 1
  • Links
    NCBI Gene ID: 126789
    neXtProt AC: NX_Q8N0Z8
    UniProt: Q8N0Z8

  • Chr Location
    1p36.33; chr1:1308597-1311677 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    34
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 433813 NCBI Gene Model | MGI Sequence Detail 2918 C57BL/6J ±  kb
transcript NM_001033490 RefSeq | MGI Sequence Detail 1229 ZRU/MplStud  
polypeptide A2ADA5 UniProt | EBI | MGI Sequence Detail 291 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013501 tRNA pseudouridine synthase-like 1
    (term hierarchy)
  • EC
    5.4.99.-
  • InterPro Domains
    IPR020103 Pseudouridine synthase, catalytic domain superfamily
    IPR001406 Pseudouridine synthase I, TruA
    IPR020097 Pseudouridine synthase I, TruA, alpha/beta domain
    IPR020095 Pseudouridine synthase I, TruA, C-terminal
    IPR020094 Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal
Molecular
Reagents
less
  • All nucleic 36
    cDNA 35
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:1923798, MGI:1933538, MGI:2140396
References
more
  • Summaries
    All 31
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:285406 Busch JD, et al., MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition. Cell Rep. 2019 Nov 5;29(6):1728-1738.e9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory