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Usp44 Gene Detail
Summary
  • Symbol
    Usp44
  • Name
    ubiquitin specific peptidase 44
  • Synonyms
    E430004F17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045318
    NCBI Gene: 327799
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:93667417-93693950 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 48.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    953 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045318
 protein coding gene Chr10:93655831-93696792 (+)
129S1/SvImJ ENSMUSG00200027823
 protein coding gene Chr10:90149668-90191657 (+)
A/J ENSMUSG00195020876
 protein coding gene Chr10:90587572-90640785 (+)
AKR/J ENSMUSG00220020484
 protein coding gene Chr10:90155121-90197291 (+)
BALB/cJ ENSMUSG00180028434
 protein coding gene Chr10:90590254-90643468 (+)
C3H/HeJ ENSMUSG00175021304
 protein coding gene Chr10:90491094-90544285 (+)
C57BL/6NJ ENSMUSG00215025427
 protein coding gene Chr10:90186127-90239229 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015737
 protein coding gene Chr10:87533013-87548285 (+)
CAST/EiJ ENSTCUG00005031430
 protein coding gene Chr10:89881088-89920581 (+)
CBA/J ENSMUSG00210034091
 protein coding gene Chr10:90326190-90379388 (+)
DBA/2J ENSMUSG00185039479
 protein coding gene Chr10:90538167-90591367 (+)
FVB/NJ ENSMUSG00205018326
 protein coding gene Chr10:90236419-90289616 (+)
JF1/MsJ ENSUMUG00000014579
 protein coding gene Chr10:91956607-91998157 (+)
LP/J ENSMUSG00230021846
 protein coding gene Chr10:92445907-92499342 (+)
NOD/ShiLtJ ENSMUSG00190017835
 protein coding gene Chr10:90575461-90628661 (+)
NZO/HlLtJ ENSMUSG00225020075
 protein coding gene Chr10:96703583-96756706 (+)
PWK/PhJ ENSLUMG00010021453
 protein coding gene Chr10:90223673-90264900 (+)
SPRET/EiJ ENSMSPG00010010022
 protein coding gene Chr10:91843790-91883328 (+)
WSB/EiJ ENSIUOG00005033836
 protein coding gene Chr10:90270717-90324038 (+)



Homology
more
  • Human Ortholog
    USP44, ubiquitin specific peptidase 44
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP44, ubiquitin specific peptidase 44
  • Links
    NCBI Gene ID: 84101
    UniProt: Q9H0E7

  • Chr Location
    12q22; chr12:95516560-95553341 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    3 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit chromosomal instability, aneuploidy and increased tumor incidence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020020 Ensembl Gene Model | MGI Sequence Detail 26534 C57BL/6J ±  kb
    transcript ENSMUST00000216224 Ensembl | MGI Sequence Detail 2449 Not Applicable  
    polypeptide ENSMUSP00000149020 Ensembl | MGI Sequence Detail 711 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000017183 ubiquitin carboxyl-terminal hydrolase 44
      (term hierarchy)
    • EC
      3.4.19.12
    • InterPro Domains
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR050185 Ubiquitin carboxyl-terminal hydrolase
      IPR018200 Ubiquitin specific protease, conserved site
      IPR028889 Ubiquitin specific protease USP, catalytic domain
      IPR013083 Zinc finger, RING/FYVE/PHD-type
      IPR001607 Zinc finger, UBP-type
    • GlyGen
      Q8C2S0 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 1
    References
    more
    • Summaries
      All 46
      Gene Ontology 12
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:357573 Liu Y, et al., USP44 inactivation accelerates the progression of thyroid cancer by inducing ubiquitylation and degradation of p21. Int J Biol Sci. 2024;20(13):5223-5238
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory