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Tlr13 Gene Detail
Summary
  • Symbol
    Tlr13
  • Name
    toll-like receptor 13
  • Synonyms
    LOC279572
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045213
    NCBI Gene: 279572
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:105186881-105204099 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 47.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    379 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045213
 protein coding gene ChrX:105186810-105204099 (+)
129S1/SvImJ ENSMUSG00200037489
 protein coding gene ChrX:86970153-86987855 (+)
A/J ENSMUSG00195037793
 protein coding gene ChrX:90700551-90718251 (+)
AKR/J ENSMUSG00220035289
 protein coding gene ChrX:85405543-85423259 (+)
BALB/cJ ENSMUSG00180040073
 protein coding gene ChrX:87366667-87384369 (+)
C3H/HeJ ENSMUSG00175040911
 protein coding gene ChrX:90942523-90960221 (+)
C57BL/6NJ ENSMUSG00215045854
 protein coding gene ChrX:87595969-87613680 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033327
 protein coding gene ChrX:100169723-100186588 (+)
CAST/EiJ ENSTCUG00005040732
 protein coding gene ChrX:88393613-88411353 (+)
CBA/J ENSMUSG00210041559
 protein coding gene ChrX:87836129-87853824 (+)
DBA/2J ENSMUSG00185043246
 protein coding gene ChrX:100290538-100308258 (+)
FVB/NJ ENSMUSG00205028145
 protein coding gene ChrX:86912477-86930188 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230040842
 protein coding gene ChrX:106967543-106985237 (+)
NOD/ShiLtJ ENSMUSG00190033991
 protein coding gene ChrX:87026947-87044668 (+)
NZO/HlLtJ ENSMUSG00225039842
 protein coding gene ChrX:112101194-112118923 (+)
PWK/PhJ ENSLUMG00010036095
 protein coding gene ChrX:86156773-86174668 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005040324
 protein coding gene ChrX:87537361-87555066 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Macrophages isolated from mice carrying an ENU-induced mutation respond normally to known TLR ligands and can contain various viral infections; however, mice carrying this allele have not been tested for immune responses in vivo.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    1
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 279572 NCBI Gene Model | MGI Sequence Detail 17219 C57BL/6J ±  kb
    transcript NM_205820 RefSeq | MGI Sequence Detail 4014 C57BL/6  
    polypeptide Q6R5N8 UniProt | EBI | MGI Sequence Detail 991 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147911, MGI:2685559
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 23
    • Earliest
      J:88906 Tabeta K, et al., Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3516-21
    • Latest
      J:368743 Sato R, et al., RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells. J Exp Med. 2025 Mar 3;222(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory