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B3gnt6 Gene Detail
Summary
  • Symbol
    B3gnt6
  • Name
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
  • Synonyms
    Core-3, Core3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039603
    NCBI Gene: 272411
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:97841622-97848682 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 53.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    300 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3039603
 protein coding gene Chr7:97841622-97848688 (-)
129S1/SvImJ ENSMUSG00200048890
 protein coding gene Chr7:84666259-84673322 (-)
A/J ENSMUSG00195036784
 protein coding gene Chr7:89171199-89178262 (-)
AKR/J ENSMUSG00220047533
 protein coding gene Chr7:82588517-82595582 (-)
BALB/cJ ENSMUSG00180026458
 protein coding gene Chr7:85844620-85851683 (-)
C3H/HeJ ENSMUSG00175022448
 protein coding gene Chr7:86492971-86500056 (-)
C57BL/6NJ ENSMUSG00215032969
 protein coding gene Chr7:85684512-85691576 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030014
 protein coding gene Chr7:100879270-100886524 (-)
CAST/EiJ ENSTCUG00005030511
 protein coding gene Chr7:89071604-89078671 (-)
CBA/J ENSMUSG00210025305
 protein coding gene Chr7:86340885-86347970 (-)
DBA/2J ENSMUSG00185029784
 protein coding gene Chr7:90667662-90674751 (-)
FVB/NJ ENSMUSG00205021884
 protein coding gene Chr7:86342978-86350041 (-)
JF1/MsJ ENSUMUG00000028716
 protein coding gene Chr7:95566243-95573362 (-)
LP/J ENSMUSG00230038214
 protein coding gene Chr7:96783250-96790317 (-)
NOD/ShiLtJ ENSMUSG00190017431
 protein coding gene Chr7:86617811-86624874 (-)
NZO/HlLtJ ENSMUSG00225048475
 protein coding gene Chr7:94969694-94976757 (-)
PWK/PhJ ENSLUMG00010046417
 protein coding gene Chr7:84796868-84803949 (-)
SPRET/EiJ ENSMSPG00010010272
 protein coding gene Chr7:86029752-86036639 (-)
WSB/EiJ ENSIUOG00005009728
 protein coding gene Chr7:86952478-86959552 (-)



Homology
more
  • Human Ortholog
    B3GNT6, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    B3GNT6, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
  • Synonyms
    B3Gn-T6, beta-1,3-Gn-T6, beta3Gn-T6, BGnT-6
  • Links
    NCBI Gene ID: 192134
    UniProt: Q6ZMB0

  • Chr Location
    11q13.5; chr11:77034398-77041973 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozgous for a knock-out allele exhibit increased permeability of the intestinal barrier, increased susceptibility to DSS-induced colitis and accelerated colorectal tumorigenesis in mice treated with AOM and DSS.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    6
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 272411 NCBI Gene Model | MGI Sequence Detail 7061 C57BL/6J ±  kb
    transcript NM_001081167 RefSeq | MGI Sequence Detail 2367 Not Specified  
    polypeptide Q3USF0 UniProt | EBI | MGI Sequence Detail 391 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 8
      Phenotypes 22
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:339673 Coletto E, et al., Role of mucin glycosylation in the gut microbiota-brain axis of core 3 O-glycan deficient mice. Sci Rep. 2023 Aug 26;13(1):13982
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory