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Wee2 Gene Detail
Summary
  • Symbol
    Wee2
  • Name
    WEE1 homolog 2 (S. pombe)
  • Synonyms
    LOC381759, Wee1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:3027899
    NCBI Gene: 381759
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr6:40416022-40443747 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 18.82 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3027899
 protein coding gene Chr6:40412180-40443749 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030607
 protein coding gene Chr6:38897354-38927152 (+)
A/J MGP_AJ_G0030580
 protein coding gene Chr6:37187351-37222481 (+)
AKR/J MGP_AKRJ_G0030507
 protein coding gene Chr6:38361946-38394882 (+)
BALB/cJ MGP_BALBcJ_G0030590
 protein coding gene Chr6:37400266-37427962 (+)
C3H/HeJ MGP_C3HHeJ_G0030303
 protein coding gene Chr6:38388574-38417587 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031044
 protein coding gene Chr6:39863960-39891121 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028256
 protein coding gene Chr6:35056881-35083930 (+)
CAST/EiJ MGP_CASTEiJ_G0029705
 protein coding gene Chr6:38313326-38342556 (+)
CBA/J MGP_CBAJ_G0030281
 protein coding gene Chr6:41456317-41487553 (+)
DBA/2J MGP_DBA2J_G0030425
 protein coding gene Chr6:36996918-37024323 (+)
FVB/NJ MGP_FVBNJ_G0030379
 protein coding gene Chr6:36781296-36812152 (+)
LP/J MGP_LPJ_G0030512
 protein coding gene Chr6:38904507-38933044 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030415
 protein coding gene Chr6:43694946-43727513 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031074
 protein coding gene Chr6:38330637-38368899 (+)
PWK/PhJ MGP_PWKPhJ_G0029419
 protein coding gene Chr6:36695320-36723139 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029255
 protein coding gene Chr6:38047718-38082475 (+)
WSB/EiJ MGP_WSBEiJ_G0029781
 protein coding gene Chr6:38279810-38307090 (+)



Homology
more
  • Human Ortholog
    WEE2, WEE2 oocyte meiosis inhibiting kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WEE2, WEE2 oocyte meiosis inhibiting kinase
  • Synonyms
    OOMD5, OZEMA5, WEE1B
  • Links
    NCBI Gene ID: 494551
    neXtProt AC: NX_P0C1S8
    UniProt: P0C1S8

  • Chr Location
    7q34; chr7:141708353-141731271 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a short deletion exhibit normal female fertility. Mice homozygous for a large deletion exhibit reduced litter size from female mice without any other changes in reproductive parameters.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    21
  • cDNA Data
    74
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037159 Ensembl Gene Model | MGI Sequence Detail 27726 C57BL/6J ±  kb
    transcript ENSMUST00000038907 Ensembl | MGI Sequence Detail 2884 Not Applicable  
    polypeptide ENSMUSP00000038754 Ensembl | MGI Sequence Detail 555 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 74
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2685911
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 5
    • Earliest
      J:87924 Nakanishi M, et al., Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases. Genes Cells. 2000 Oct;5(10):839-47
    • Latest
      J:339125 Nozawa K, et al., Oocyte-specific Wee1-like protein kinase 2 is dispensable for fertility in mice. PLoS One. 2023;18(8):e0289083
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory