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Myo16 Gene Detail
Summary
  • Symbol
    Myo16
  • Name
    myosin XVI
  • Synonyms
    BM140241, C230040D10Rik, Nyap3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685951
    NCBI Gene: 244281
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:10203911-10684742 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 4.77 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    15239 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685951
 protein coding gene Chr8:10203911-10684742 (+)
129S1/SvImJ ENSMUSG00200009766
 protein coding gene Chr8:7083372-7565635 (+)
A/J ENSMUSG00195008782
 protein coding gene Chr8:7442707-7924992 (+)
AKR/J ENSMUSG00220010415
 protein coding gene Chr8:7167991-7650314 (+)
BALB/cJ ENSMUSG00180004585
 protein coding gene Chr8:7081773-7564092 (+)
C3H/HeJ ENSMUSG00175007254
 protein coding gene Chr8:7234548-7717025 (+)
C57BL/6NJ ENSMUSG00215006047
 protein coding gene Chr8:7116163-7598459 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030812
 protein coding gene Chr8:6689536-7067775 (+)
CAST/EiJ ENSTCUG00005019774
 protein coding gene Chr8:7067621-7549888 (+)
CBA/J ENSMUSG00210010168
 protein coding gene Chr8:7075774-7558062 (+)
DBA/2J ENSMUSG00185003656
 protein coding gene Chr8:7208557-7690812 (+)
FVB/NJ ENSMUSG00205004595
 protein coding gene Chr8:7095535-7577940 (+)
JF1/MsJ ENSUMUG00000036601
 protein coding gene Chr8:7208541-7694494 (+)
LP/J ENSMUSG00230007079
 protein coding gene Chr8:9386362-9868555 (+)
NOD/ShiLtJ ENSMUSG00190010806
 protein coding gene Chr8:7193576-7675842 (+)
NZO/HlLtJ ENSMUSG00225016068
 protein coding gene Chr8:17243431-17725694 (+)
PWK/PhJ ENSLUMG00010010345
 protein coding gene Chr8:7130667-7618047 (+)
SPRET/EiJ ENSMSPG00010016391
 protein coding gene Chr8:7238001-7743702 (+)
WSB/EiJ ENSIUOG00005004158
 protein coding gene Chr8:7083172-7575224 (+)



Homology
more
  • Human Ortholog
    MYO16, myosin XVI
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYO16, myosin XVI
  • Synonyms
    MYAP3, Myo16b, MYR8, NYAP3, PPP1R107
  • Links
    NCBI Gene ID: 23026
    UniProt: Q9Y6X6

  • Chr Location
    13q33.3; chr13:108495716-109208005 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from multigenic genotypes
    6 phenotype references
Triple KO of Nyap1, Nyap2 and Myo16 results in decreased brain weight and cortex and striatum size and reduced neurite length in cortical neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    648
  • Tissues
    10
  • cDNA Data
    26
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 244281 NCBI Gene Model | MGI Sequence Detail 480832 C57BL/6J ±  kb
transcript NM_001319151 RefSeq | MGI Sequence Detail 7252 C57BL/6  
polypeptide Q5DU14 UniProt | EBI | MGI Sequence Detail 1919 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010851 myosin-XVI
    (term hierarchy)
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR036770 Ankyrin repeat-containing domain superfamily
    IPR036042 Class XVI myosin, motor domain
    IPR036961 Kinesin motor domain superfamily
    IPR001609 Myosin head, motor domain-like
    IPR029353 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, C-terminal domain
    IPR039482 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, N-terminal
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR052838 Unconventional myosin-XVI
  • GlyGen
    Q5DU14 3 sites, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 28
    cDNA 27
    Primer pair 1

    Microarray probesets 1
Other
Accession IDs
less
MGI:3623805
References
more
  • Summaries
    All 33
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:106181 Chiellini C, et al., Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. J Cell Physiol. 2003 May;195(2):309-21
  • Latest
    J:381126 Piniella D, et al., Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter. Cell Mol Life Sci. 2021 Dec;78(23):7733-7756
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory