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Irgc Gene Detail
Summary
  • Symbol
    Irgc
  • Name
    immunity related GTPase cinema
  • Synonyms
    F630044M05Rik, Iigp5, Irgc1, LOC210145, LOC381989
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685948
    NCBI Gene: 210145
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24131344-24145107 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 10.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685948
 protein coding gene Chr7:24131344-24151722 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031828
 protein coding gene Chr7:22752983-22773587 (-)
A/J MGP_AJ_G0031807
 protein coding gene Chr7:22234304-22254573 (-)
AKR/J MGP_AKRJ_G0031736
 protein coding gene Chr7:22734293-22754572 (-)
BALB/cJ MGP_BALBcJ_G0031813
 protein coding gene Chr7:22441031-22467937 (-)
C3H/HeJ MGP_C3HHeJ_G0031533
 protein coding gene Chr7:23142337-23167267 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032276
 protein coding gene Chr7:23498072-23522107 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029334
 protein coding gene Chr7:23705146-23725619 (-)
CAST/EiJ MGP_CASTEiJ_G0030874
 protein coding gene Chr7:16605750-16633096 (-)
CBA/J MGP_CBAJ_G0031498
 protein coding gene Chr7:24382244-24406654 (-)
DBA/2J MGP_DBA2J_G0031652
 protein coding gene Chr7:22147911-22168141 (-)
FVB/NJ MGP_FVBNJ_G0031605
 protein coding gene Chr7:22107106-22128905 (-)
LP/J MGP_LPJ_G0031731
 protein coding gene Chr7:23104112-23127972 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031642
 protein coding gene Chr7:24160582-24181440 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032308
 protein coding gene Chr7:22446809-22468021 (-)
PWK/PhJ MGP_PWKPhJ_G0030598
 protein coding gene Chr7:17013530-17057127 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030428
 protein coding gene Chr7:13779439-13800072 (-)
WSB/EiJ MGP_WSBEiJ_G0030977
 protein coding gene Chr7:22570466-22590526 (-)



Homology
more
  • Human Ortholog
    IRGC, immunity related GTPase cinema
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRGC, immunity related GTPase cinema
  • Synonyms
    CINEMA, IFGGE, Iigp5, IRGC1, R30953_1
  • Links
    NCBI Gene ID: 56269
    neXtProt AC: NX_Q6NXR0
    UniProt: Q6NXR0

  • Chr Location
    19q13.31; chr19:43716076-43720021 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced male fertility associated with short sperm flagellum, decreased sperm progressive motility, impaired sperm penetration of zona pellucida, and disorganized sperm fibrous sheath morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 210145 NCBI Gene Model | MGI Sequence Detail 13764 C57BL/6J ±  kb
    transcript NM_199013 RefSeq | MGI Sequence Detail 1831 Not Specified  
    polypeptide Q8C262 UniProt | EBI | MGI Sequence Detail 412 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2685320
    References
    more
    • Summaries
      All 30
      Gene Ontology 7
      Phenotypes 5
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:345052 Li J, et al., The immunity-related GTPase IRGC mediates interaction between lipid droplets and mitochondria to facilitate sperm motility. FEBS Lett. 2023 Jun;597(12):1595-1605
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory