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Jaml Gene Detail
Summary
  • Symbol
    Jaml
  • Name
    junction adhesion molecule like
  • Synonyms
    Amica1, LOC270152
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685484
    NCBI Gene: 270152
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44990481-45019832 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1016 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685484
 protein coding gene Chr9:44990451-45019832 (+)
129S1/SvImJ ENSMUSG00200018170
 protein coding gene Chr9:42072404-42097277 (+)
A/J ENSMUSG00195021797
 protein coding gene Chr9:41839517-41864115 (+)
AKR/J ENSMUSG00220033657
 protein coding gene Chr9:41917663-41942230 (+)
BALB/cJ ENSMUSG00180025859
 protein coding gene Chr9:41951231-41975831 (+)
C3H/HeJ ENSMUSG00175015367
 protein coding gene Chr9:41963124-41987723 (+)
C57BL/6NJ ENSMUSG00215015640
 protein coding gene Chr9:41915584-41940175 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032137
 protein coding gene Chr9:41955551-41985542 (+)
CAST/EiJ ENSTCUG00005014503
 protein coding gene Chr9:41901467-41925649 (+)
CBA/J ENSMUSG00210015624
 protein coding gene Chr9:42001324-42025905 (+)
DBA/2J ENSMUSG00185009441
 protein coding gene Chr9:42077798-42102396 (+)
FVB/NJ ENSMUSG00205030590
 protein coding gene Chr9:42317053-42341632 (+)
JF1/MsJ ENSUMUG00000015230
 protein coding gene Chr9:42112209-42137082 (+)
LP/J ENSMUSG00230041647
 protein coding gene Chr9:42362834-42387706 (+)
NOD/ShiLtJ ENSMUSG00190019377
 protein coding gene Chr9:42156751-42181345 (+)
NZO/HlLtJ ENSMUSG00225042582
 protein coding gene Chr9:42330750-42355316 (+)
PWK/PhJ ENSLUMG00010019572
 protein coding gene Chr9:42072193-42096750 (+)
SPRET/EiJ ENSMSPG00010010131
 protein coding gene Chr9:42828048-42856971 (+)
WSB/EiJ ENSIUOG00005019807
 protein coding gene Chr9:41561824-41586419 (+)



Homology
more
  • Human Ortholog
    JAML, junction adhesion molecule like
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JAML, junction adhesion molecule like
  • Synonyms
    AMICA, AMICA1, CREA7-1, CREA7-4, Gm638
  • Links
    NCBI Gene ID: 120425
    UniProt: Q86YT9

  • Chr Location
    11q23.3; chr11:118193725-118226323 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in the kidney exhibit protection from induced kidney injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    600
  • Tissues
    2
  • cDNA Data
    17
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048534 Ensembl Gene Model | MGI Sequence Detail 29352 C57BL/6J ±  kb
    transcript ENSMUST00000050020 Ensembl | MGI Sequence Detail 2461 Not Applicable  
    polypeptide ENSMUSP00000052033 Ensembl | MGI Sequence Detail 379 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 1
      Other 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:360473 Huang W, et al., JAML promotes acute kidney injury mainly through a macrophage-dependent mechanism. JCI Insight. 2022 Jun 16;7(14)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory