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Samd3 Gene Detail
Summary
  • Symbol
    Samd3
  • Name
    sterile alpha motif domain containing 3
  • Synonyms
    LOC268288
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685469
    NCBI Gene: 268288
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:26105605-26148070 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 13.57 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    243 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685469
 protein coding gene Chr10:26105465-26148814 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017102
 protein coding gene Chr10:24271497-24318259 (+)
A/J MGP_AJ_G0017079
 protein coding gene Chr10:23531798-23575967 (+)
AKR/J MGP_AKRJ_G0017039
 protein coding gene Chr10:23923400-23971535 (+)
BALB/cJ MGP_BALBcJ_G0017042
 protein coding gene Chr10:23666899-23709843 (+)
C3H/HeJ MGP_C3HHeJ_G0016862
 protein coding gene Chr10:24136997-24183642 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017500
 protein coding gene Chr10:25031614-25077873 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015198
 protein coding gene Chr10:22178726-22237545 (+)
CAST/EiJ MGP_CASTEiJ_G0016441
 protein coding gene Chr10:24143134-24191444 (+)
CBA/J MGP_CBAJ_G0016836
 protein coding gene Chr10:26218838-26262847 (+)
DBA/2J MGP_DBA2J_G0016941
 protein coding gene Chr10:23268417-23311588 (+)
FVB/NJ MGP_FVBNJ_G0016936
 protein coding gene Chr10:22954133-22998572 (+)
LP/J MGP_LPJ_G0017018
 protein coding gene Chr10:24277094-24324086 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016966
 protein coding gene Chr10:26201254-26247066 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017536
 protein coding gene Chr10:23807557-23853635 (+)
PWK/PhJ MGP_PWKPhJ_G0016223
 protein coding gene Chr10:23073085-23117190 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016007
 protein coding gene Chr10:23628417-23674390 (+)
WSB/EiJ MGP_WSBEiJ_G0016504
 protein coding gene Chr10:23943943-23987403 (+)



Homology
more
  • Human Ortholog
    SAMD3, sterile alpha motif domain containing 3
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAMD3, sterile alpha motif domain containing 3
  • Links
    NCBI Gene ID: 154075
    neXtProt AC: NX_Q8N6K7
    UniProt: Q8N6K7

  • Chr Location
    6q23.1; chr6:130142752-130365868 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased memory CD8+ cells and normal response to acute Vaccinia virus or chronic Lymphocytic choriomeningitis virus.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    872
  • Tissues
    95
  • cDNA Data
    7
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051354 Ensembl Gene Model | MGI Sequence Detail 42466 C57BL/6J ±  kb
    transcript ENSMUST00000220219 Ensembl | MGI Sequence Detail 1744 Not Applicable  
    polypeptide ENSMUSP00000151558 Ensembl | MGI Sequence Detail 514 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 2
      Other 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 5
      Phenotypes 9
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:322359 Peters AE, et al., A multifunctional mouse model to study the role of Samd3. Eur J Immunol. 2022 Feb;52(2):328-337
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory